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QNZ 46

4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid

A Potent and Selective Antagonist of GluN2C/GluN2D-Containing NMDA Receptors

Cat #: Q-270
Alternative Name 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic.
    MW: 443.41
    Purity: >99%
    Effective concentration 1-50 µM.
    Structure
    Chemical name 4-[6-methoxy-2-[(E)-2-(3-nitrophenyl)ethenyl]-4-oxoquinazolin-3-yl]benzoic acid.
    Molecular formula C24H17N3O6.
    CAS No.: 1237744-13-6
    PubChem CID 46861929
    Activity QNZ-46 is a potent, noncompetitive NMDA receptor antagonist, exhibiting significant selectivity for NR2D and NR2C-containing receptors (IC50 = 3 µM and 6 µM, respectively) over NR2A and NR2B-containing receptors (IC50 = 229 µM and >300 µM, respectively)1.
    References-Activity
    1. Hansen, K.B. and Traynelis, S.F. (2011) J. Neurosci. 31, 3650.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in DMSO up to 10 mM with gentle warming. Centrifuge all products before handling (10000 x g 5 min).
    Storage of solutions Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.
    Our bioassay
    • Alomone Labs QNZ 46 inhibits NMDA receptors (NR1+NR2C) expressed in Xenopus oocytes.
      Alomone Labs QNZ 46 inhibits NMDA receptors (NR1+NR2C) expressed in Xenopus oocytes.
      A. Representative time course of NR1/NR2C currents, elicited by transient stimulation with 100 µM glutamate + 100 µM glycine every 50 sec, while membrane potential was held at -80 mV, and reversibly inhibited by 4 µM and 20 µM QNZ 46 (#Q-270). B. Superimposed current traces from the recording shown in A, following application of control, 4 µM and 20 µM QNZ-46. Transient stimulation is indicated by an arrow.
    References - Scientific background
    1. Hansen, K.B. and Traynelis, S.F. (2011) J. Neurosci. 31, 3650.
    2. Black, S.A. et al. (2014) Front. Cell Dev. Biol. 2, 45.
    Scientific background

    QNZ 46 is a potent and selective antagonist of GluN2C/GluN2D-containing N-methyl-D-aspartate (NMDA) receptors. It inhibits NMDA receptor function in a non-competitive and voltage-independent manner1. The compound demonstrates IC50 value of 3.9 and 7.1 µM for NR2D and NR2C containing receptors respectively and 182 and over 193 µM for NR2A and NR2B-containing receptors1.

    NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play an important role in a variety of cellular processes and physiological functions such as, synaptic plasticity, learning and memory formation, addiction and stroke, and are important components in glutamate excitotoxicity. NMDA receptors are also involved in many neurodegenerative conditions including Alzheimer’s disease2.

    Target NMDA receptors
    Lyophilized Powder
    Last update: 02/01/2022

    QNZ 46 (#Q-270) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use
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