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RY796

A Blocker of KV2 Channels

Cat #: R-160
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 353.5
    Purity: >99.5%
    Form Lyophilized powder.
    Effective concentration 0.1-10 µM.
    Structure
    Chemical name 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide.
    Molecular formula C21H27N3O2.
    CAS No.: 1393441-53-6
    PubChem CID 76850157
    Activity RY796 is a blocker of KV2.2 and KV2.1 channels, with IC50 of 0.09 and 0.25 µM respectively1.
    References-Activity
    1. Herrington, J. et al. (2011) Mol. Pharmacol. 80, 959.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 100 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs RY796 inhibits KV2.1 channels expressed in Xenopus oocytes. 
      Alomone Labs RY796 inhibits KV2.1 channels expressed in Xenopus oocytes. 
      A. Time course of KV2.1 current amplitude, elicited by 100 ms voltage step from holding potential of -100 mV to +50 mV,delivered every 10 seconds. Application of 1 and 10 µM RY796 (#R-160) inhibits the KV2.1 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 1 and 10 µM RY796 as indicated.
    References - Scientific background
    1. Herrington, J. et al. (2011) Mol. Pharmacol. 80, 959.
    2. Li, X.N. et al. (2013) J. Pharmacol. Exp. Ther. 344, 407.
    Scientific background

    KV channels are voltage-gated potassium channels that open in response to membrane depolarization thus serving as key elements after cell repolarization. KV channels regulate numerous physiological processes. KV2 channels are widely expressed in the CNS, pancreas and smooth muscle.

    RY796 is a synthetic blocker of the KV2.1 and KV2.2 channels. It has an effective concentration of 0.1-10 µM and an IC50 of 0.09 µM and 0.25 µM for the KV2.1 and KV2.2 channels respectively. RY796 has greater selectivity for KV2 channels over other KV channels out of 1894 compounds in a study conducted by Herrington, J. et al. In addition, RY796 does not affect other ion channels such as sodium and calcium.

    RY796 blocks the KV channel in a use and dose dependent manner1. In an experiment examining the role of KV channels in the regulation of insulin and somatostatin release from pancreatic islets, RY796 caused an increase of GSIS (glucose stimulated insulin secretion) in vitro however not producing the same effect in live mice. RY796 was also found to increase glucose stimulated somatostatin release from pancreatic δ-cells2.

    Target KV2 channels
    Last update: 12/08/2021

    RY796 (#R-160) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Shipping and Ordering information