K⁺ selective channels are some of the most widespread ion trafficking molecules in living organisms, with more than 70 genes encoding different K⁺ channels in humans. K_V channels fall into one of the two classical categories of delayed rectifier (DR) and A-type. Delayed rectifier was the original name attributed to voltage-dependent K⁺ channels due to their delayed activation in squid giant axons. A-type channels are low voltage-activated, fast inactivating (therefore, transient) K⁺ channels. Specific K_V toxins are often used to dissect the particular contribution of different subunits to native currents.

Alomone Labs is pleased to offer the Shaker (K_V)-Related Channel Blocker Explorer Kit (#EK-108). This Explorer Kit includes peptide toxins known to block K_V2, K_V3 and K_V4 channels. An ideal tool for screening purposes.