Certificate of Analysis

TRPM8 Channel Activator Explorer Kit

A Screening Package of TRPM8 Channel Activators Economically Priced
Cat #: EK-150 5 Vials

D-3263 hydrochloride Cat #: D-195

Size: 5 mg Source: Synthetic MW: 409.95 Purity: >97%
Effective concentration
1 nM – 10 µM.
Activity
D-3263 hydrochloride is a potent TRPM8 channel agonist1.
It shows evidence of activity in preclinical tumor models and was tested in phase 1 clinical trials for the treatment of prostate cancer1-3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

Frescolat MGA Cat #: F-165

Size: 1 g Source: Synthetic MW: 228.33 Purity: >97%
Effective concentration
0.1-10 µM.
Activity
Frescolat MGA is a TRPM8 channel activator and cooling agent. It activates mouse TRPM8 channels with EC50 of 4.8 µM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Store in a cool and dry place.
Reconstitution
Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

Icilin Cat #: I-145

Size: 5 mg Source: Synthetic MW: 311.29 Purity: >95%
Effective concentration
1 nM – 1 µM.
Activity
Icilin is a potent TRPM8 channel activator (EC50 = 0.2 µM)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

WS 3 Cat #: W-100

Size: 1 g Source: Synthetic MW: 211.34 Purity: >98%
Effective concentration
0.1-10 µM.
Activity
WS 3 is a TRPM8 channel activator (EC50 = 3.7 μM)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 100mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

WS 12 Cat #: W-105

Size: 5 mg Source: Synthetic MW: 289.41 Purity: >99%
Effective concentration
1 nM – 10 µM.
Activity
WS 12 is a TRPM8 channel activator (EC50 = 193 nM)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 75 mM in Ethanol. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.