TRPM8 Channel Modulator Explorer Kit

TRPM8 channel is the cold and menthol receptor activated by either cold temperatures(~28°C) or menthol.¹

TRPM8 is expressed in dorsal root ganglia (DRGs) where about 5%-10% of the small diameter DRG neurons express the channel.^2,3 In DRGs, TRPM8 expressing neurons do not express the TRPV1 channel.⁴ Overexpression of TRPM8 was found in prostate cancer cells. However, the physiological and pathological roles that these cells play is still elusive.⁵ In prostate, it was suggested that TRPM8 might play a possible role in the progression of cancer to the metastatic stage.⁵