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YM 90K hydrochloride

A Potent Antagonist of AMPA Receptors

Cat #: Y-105
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 309.9
    Purity: >99%
    Form Lyophilized powder.
    Effective concentration 50 nM - 50 µM.
    Structure
    Chemical name 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione hydrochloride.
    Molecular formula C11H8ClN5O4.
    CAS No.: 154164-30-4
    Activity YM 90K hydrochloride is a selective AMPA receptor antagonist; Ki of 84 nM1.
    References-Activity
    1. Ohmori, J. et al. (1994) J. Med. Chem. 37, 467.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 10 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs YM 90K hydrochloride inhibits GluA1 channels heterologously expressed in Xenopus oocytes.
      Alomone Labs YM 90K hydrochloride inhibits GluA1 channels heterologously expressed in Xenopus oocytes.
      Time course of reversible current inhibition by 10 μM YM 90K hydrochloride (#Y-105) of glutamate-elicited currents (100 μM, holding potential -80 mV).
    References - Scientific background
    1. Shimizu-Sasamata, M. et al. (1996) J. Pharmacol. Exp. Ther. 276, 84.
    2. Kodama, M. et al. (1999) Eur. J. Pharmacol. 374, 11.
    Scientific background

    YM 90K is a selective and potent AMPA receptor antagonist. YM 90K inhibits the binding of [3H] AMPA with a Ki value of 84 nM1.

    YM 90K has been reported to have neuroprotective effects in focal and global cerebral ischaemia models. However, high or moderate doses of YM 90K induce behavioral changes, including sedation, muscular hypotonia and ataxia. In addition, the effects of YM 90K are short-lived. In this context, YM 90K may be useful for the treatment of acute epileptic conditions such as status epilepticus. Moreover, it might prevent pathological neuronal plasticity resulting from status epilepticus, since it shows an antiepileptogenic effect and protects hippocampal neurons during kainate-induced generalized seizures.

    YM 90K could be clinically useful, since a low dose exhibits significant, although weak effects against kindling without detectable behavioral adverse effects2.

    Target AMPA receptors
    Lyophilized Powder
    Last update: 12/08/2021

    YM 90K hydrochloride (#Y-105) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use
    Shipping and Ordering information

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