No generalizations about the role of this enigmatic receptor in cancer can be made. As in all other aspects of …
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Articles
K+ Channels and Cancer: Surprising New Discoveries
K+ channels belong to a large class of transmembrane proteins that specifically regulate the transport of K+ ions across biological …
Continue readingLive or Let Die in Neuroscience: The Story of the Proneurotrophins
Although it has been more than forty years since the neurotrophins were first discovered we are only now starting to …
Continue readingSomatostatin and the Somatostatin Receptors: Versatile Regulators of Biological Activity
It has been more than thirty years since the discovery of a small tetradecapeptide that was able to inhibit the …
Continue readingP2Y Receptors: Mediators of Extracellular Nucleotide Actions
The notion that adenine and uridine nucleotides could function as extracellular signaling molecules was met with considerable resistance when it …
Continue readingThe Hype on the Endothelin Signaling System
Over the past two decades, research in the endothelin signaling system has been quite intensive since they are profoundly involved …
Continue readingMuscarinic Receptor Family
The muscarinic receptors belong to the G-protein coupled receptors (GPCR) family. In mammals, at least five different muscarinic acetylcholine receptor …
Continue readingExploring P2Y Receptors
Following hypoxia or inflammation, extracellular nucleotide release can activate two families of receptors, the ionotropic P2X receptors with seven subtypes …
Continue readingGABA (B) Receptors: an Example of Subtle Modulations in a Neurotransmitter System
The “GABAergic” system is the main inhibitory network in the central nervous system and as such influences almost every aspect …
Continue readingThe Brains on Adenosine Receptors
Adenosine is a small ubiquitous molecule known for its role as an energy and genetic code building block. Adenosine also …
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