Angiotensin II Receptor Antagonist Explorer Kit

A Screening Package of Angiotensin II Receptor Antagonists Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
Cat #: EK-370
Sizes: 8 Vials
Last update: 23/07/2019

Alomone Labs is pleased to offer the Angiotensin II Receptor Antagonist Explorer Kit (#EK-370). The Explorer Kit contains angiotensin II receptor antagonists, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Azilsartan
A-245 1 x 10 mg
Candesartan
C-266 1 x 50 mg
EMD 66684
E-160 1 x 5 mg
Eprosartan mesylate
E-145 1 x 50 mg
Losartan potassium
L-185 1 x 500 mg
Olmesartan
O-125 1 x 100 mg
Telmisartan
T-170 1 x 50 mg
Valsartan
V-120 1 x 50 mg
References
    • Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen precursor protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.

      Most of the physiological actions of Ang II are mediated by AT1; a member of the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.

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