Angiotensin II Receptor Basic Research Pack

All You Need for Angiotensin II Receptor Research
  • Lyophilized Powder
  • Antigen Incl.
  • Bioassay Tested
  • Shipped at Room Temp.
  • 100% Net Peptide
Cat #: ESB-950
Sizes: 8 Vials
Last update: 07/10/2018

Alomone Labs is pleased to offer the Angiotensin II Receptor Basic Research Pack (#ESB-950). The Research Pack contains all you need for angiotensin II receptor research, all in one economical package!

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-Angiotensin II Receptor Type-1 (extracellular) Antibody
AAR-011 1 x 0.2 ml
Anti-Angiotensin II Receptor Type-2 (extracellular) Antibody
AAR-012 1 x 0.2 ml
Angiotensin A (1-8)
SPA-105 1 x 10 mg
Angiotensin II acetate
SPA-165 1 x 50 mg
Azilsartan
A-245 1 x 50 mg
PD 123319 ditrifluoroacetate
P-245 1 x 25 mg
Scientific Background
Scientific Background

Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.

Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.

References
  1. Mukoyama, M. et al. (1993) J. Biol. Chem268, 24539.
  2. De Gasparo, M. et al. (2000) Pharmacol. Rev. 52, 415.
  3. Carey, R.M. and Siragy, H.M. (2003) Endocr. Rev24, 261.
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