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Angiotensin II Receptor Deluxe Research Pack

All You Need for Angiotensin II Receptor Research
  • Lyophilized Powder
  • Antigen Incl.
Cat #: ESD-950
Sizes: 16 Vials
Last update: 01/07/2019

Alomone Labs is pleased to offer the Angiotensin II Receptor Deluxe Research Pack (#ESD-950). The Research Pack contains all you need for angiotensin II receptor research, all in one economical package!

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Antibodies
Anti-Angiotensin II Receptor Type-1 (extracellular) Antibody
 		AAR-011 1 x 0.2 ml
Anti-Angiotensin II Receptor Type-1 (extracellular)-ATTO-550 Antibody
 		AAR-011-AO 1 x 50 µl
Anti-Angiotensin II Receptor Type-2 (extracellular) Antibody
 		AAR-012 1 x 0.2 ml
Anti-Angiotensin II Receptor Type-2 (extracellular)-ATTO-488 Antibody
 		AAR-012-AG 1 x 50 µl
Activators/Agonists
Angiotensin A (1-8)
 		SPA-105 1 x 10 mg
Angiotensin II acetate
 		SPA-165 1 x 50 mg
[D-Ala7]-Angiotensin I/II (1-7)
 		SPA-160 1 x 10 mg
Novokinin
 		SPA-125 1 x 5 mg
Blockers/Antagonists
Azilsartan
 		A-245 1 x 50 mg
Candesartan cilexetil
 		C-265 1 x 1 g
PD 123319 ditrifluoroacetate
 		P-245 1 x 25 mg
Telmisartan
 		T-170 1 x 1 g
Scientific Background

    • Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.

      Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.
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