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Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.
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Antigen Incl. Control Antigen IncludedThis antibody is shipped with its antigen FREE of charge!
Alomone Labs is pleased to offer the Angiotensin II Receptor Deluxe Research Pack (#ESD-950). The Research Pack contains all you need for angiotensin II receptor research, all in one economical package!
Compounds
| Product Name | Cat # | Size |
|---|---|---|
| Antibodies | ||
Anti-Angiotensin II Receptor Type-1 (extracellular) Antibody | AAR-011 | 1 x 0.2 ml |
Anti-Angiotensin II Receptor Type-1 (extracellular)-ATTO-550 Antibody | AAR-011-AO | 1 x 50 µl |
Anti-Angiotensin II Receptor Type-2 (extracellular) Antibody | AAR-012 | 1 x 0.2 ml |
Anti-Angiotensin II Receptor Type-2 (extracellular)-ATTO-488 Antibody | AAR-012-AG | 1 x 50 µl |
| Activators/Agonists | ||
Angiotensin A (1-8) | SPA-105 | 1 x 10 mg |
Angiotensin II acetate | SPA-165 | 1 x 50 mg |
[D-Ala7]-Angiotensin I/II (1-7) | SPA-160 | 1 x 10 mg |
Novokinin | SPA-125 | 1 x 5 mg |
| Blockers/Antagonists | ||
Azilsartan | A-245 | 1 x 50 mg |
Candesartan cilexetil | C-265 | 1 x 1 g |
PD 123319 ditrifluoroacetate | P-245 | 1 x 25 mg |
Telmisartan | T-170 | 1 x 1 g |
Scientific Background
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Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.
Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.
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- Mukoyama, M. et al. (1993) J. Biol. Chem. 268, 24539.
- De Gasparo, M. et al. (2000) Pharmacol. Rev. 52, 415.
- Carey, R.M. and Siragy, H.M. (2003) Endocr. Rev. 24, 261.
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