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Angiotensin II

Ang II, Angiotensin-2

A Ligand of AT1 and AT2 G-Protein Coupled Receptors

Cat #: GPA-100
Alternative Name Ang II, Angiotensin-2
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Synthetic peptide
    MW: 1046.2 Da
    Purity: >98% (HPLC)
    Effective concentration 1-300 nM.
    Sequence DRVYIHPF.
    Structure
    Molecular formula C50H71N13O12.
    CAS No.: 4474-91-3
    Activity Angiotensin II regulates blood vessel tonus, blood pressure, and salt and water balance1-3.
    References-Activity
    1. Watanabe, T. et al. (2005) Hypertension 45, 163.
    2. Keidar, S. et al. (2007) Cardiovasc Res. 73, 463.
    3. Gendron, L. et al. (1999) Mol. Endocrinol. 13, 1615.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to one week at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Angiotensin II induces MAPK activation in IEC-6 cells.
      Alomone Labs Angiotensin II induces MAPK activation in IEC-6 cells.
      Cells were incubated in serum depleted medium for 2 h and then stimulated with 100 nM Angiotensin II (#GPA-100) for 5 or 10 min. Cell proteins were resolved by SDS-PAGE and probed with anti-phospo-ERK1/2.
    References - Scientific background
    1. Basso, N. and Terragno, N.A. (2001) Hypertension 38, 1246.
    2. Santos, R.A. et al. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 8258.
    3. Kim, S. and Iwao, H. (2000) Pharmacol. Rev. 52, 11.
    4. Dinh, D.T. et al. (2001) Clinical Science 100, 481.
    Scientific background

    Angiotensin II (Ang II) is a key factor in the Renin-Angiotensin-Aldosterone (RAAS) system. Ang II is a derivative of a precursor molecule – angiotensinogen, a member of the serpin family. Angiotensinogen is a substrate of the Renin in the kidney to produce a deca peptide – Ang I, which appears to have no biological activity. Ang I is converted to Ang II by Angiotensin-Converting Enzyme (ACE)1,2.

    The biological effects caused by Ang II are mediated by four Ang II receptor subtypes: AT1 and AT2. Ang II plays a critical role in the regulation of the renal and cardiovascular systems, and some activities in the central nervous systems. Circulating levels of Ang II were identified as controlling blood pressure, based on the regulation of salt and water metabolism, vascular smooth muscle cell tone, thirst, and sympathetic system outflow. Ang II is well known to cause potent increases in systemic and local blood pressure via its vasoconstrictive effect, to influence renal tubules, to retain Na+ and water by activating Na+/H+ exchangers, and by stimulating aldosterone release from the adrenal gland3.

    Ang II is also a cell growth modulator depending on the Ang II receptor subtype expressed in the cell membrane. It may either stimulate growth (proliferation, hypertrophy) or act as a growth suppressor3,4.

    Target Angiotensin II receptors
    Peptide Content: 100%
    Lyophilized Powder
    Last update: 08/06/2021

    Angiotensin II (GPA-100) is a highly pure, synthetic, and biologically active peptide.

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    For research purposes only, not for human use
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