Angiotensin II Receptor Pharmacology Explorer Kit

A Screening Package of Angiotensin II Receptor Pharmacology Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
Cat #: EK-405
Sizes: 10 Vials
Last update: 24/04/2019

Angiotensin II Receptor Pharmacology Explorer Kit (#EK-405) contains Angiotensin Receptors Type I and II agonists and antagonists, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Angiotensin A (1-8)
SPA-105 1 x 5 mg
[D-Ala7]-Angiotensin I/II (1-7)
SPA-160 1 x 1 mg
Angiotensin II acetate
SPA-165 1 x 5 mg
Azilsartan
A-245 1 x 10 mg
Candesartan cilexetil
C-265 1 x 250 mg
EMD 66684
E-160 1 x 5 mg
Eprosartan mesylate
E-145 1 x 50 mg
Losartan potassium
L-185 1 x 500 mg
Novokinin
SPA-125 1 x 1 mg
PD 123319 ditrifluoroacetate
P-245 1 x 5 mg
References
Scientific Background

Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.

Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.

References
  1. Mukoyama, M. et al. (1993) J. Biol. Chem268, 24539.
  2. De Gasparo, M. et al. (2000) Pharmacol. Rev. 52, 415.
  3. Carey, R.M. and Siragy, H.M. (2003) Endocr. Rev24, 261.
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