Angiotensin II Receptor Pharmacology Explorer Kit (#EK-405) contains Angiotensin Receptors Type I and II agonists and antagonists, ideal for screening purposes.
|Product Name||Cat #||Size|
|SPA-105||1 x 5 mg|
|SPA-160||1 x 1 mg|
|SPA-165||1 x 5 mg|
|A-245||1 x 10 mg|
|C-265||1 x 250 mg|
|E-160||1 x 5 mg|
|E-145||1 x 50 mg|
|L-185||1 x 500 mg|
|SPA-125||1 x 1 mg|
|P-245||1 x 5 mg|
Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.
Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.
- Anti-Angiotensin II Receptor Type-1 (extracellular) Antibody (#AAR-011)
- Anti-Angiotensin II Receptor Type-2 (extracellular) Antibody (#AAR-012)
- Angiotensin II (#GPA-100)
- Angiotensin III (#GPA-130)
- Angiotensin II Receptor Antagonist Explorer Kit (#EK-370)
- Angiotensin II Receptor Basic Research Pack (#ESB-950)
- Angiotensin II Receptor Premium Research Pack (#ESP-950)
- Angiotensin II Receptor Deluxe Research Pack (#ESD-950)