ASIC3 Channel Premium Research Pack

All You Need for ASIC3 Channel Research
  • Lyophilized Powder
  • Antigen Incl.
  • Bioassay Tested
  • Shipped at Room Temp.
  • 100% Net Peptide
Cat #: ESP-201
Sizes: 13 Vials
Last update: 04/09/2018

Alomone Labs is pleased to offer the ASIC3 Channel Premium Research Pack (#ESP-201). The Research Pack contains all you need for ASIC3 channel research: Antibodies recognizing different domains of the channel, membrane lysates expressing ASIC3 channel- your ideal control for western blot analysis and specific ASIC3 channel activator and blockers, all in one economical package!

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-ASIC3 Antibody
ASC-018 1 x 0.2 ml
Guinea pig Anti-ASIC3 Antibody
AGP-052 1 x 0.2 ml
Anti-pan ASIC (extracellular) Antibody
ASC-031 1 x 0.2 ml
ASIC3 Channel Overexpressed Membrane Fractions
LX-100 2 x 0.1 ml
APETx2
STA-160 1 x 0.1 mg
Cono AIVGRPRF-amide
STC-174 1 x 0.5 mg
Cono RPRF-amide
STC-170 1 x 0.5 mg
Cono VGRPRF-amide
STC-172 1 x 0.5 mg
GMQ hydrochloride
G-165 1 x 50 mg
Note

A guinea pig polyclonal antibody (#AGP-052) is included in this Research Pack. Please take into account when reacting with a secondary antibody.

ASIC3 Channel Overexpressed Membrane Fractions includes:
1 x 0.1 ml lyophilized ASIC3 channel overexpressed membrane fractions
1 x 0.1 ml lyophilized non-injected Xenopus oocyte membrane fractions

Scientific Background
Scientific Background

ASIC3 is a member of a family of Na+ channels that are activated by external protons. The family includes another three members ASIC1ASIC2 and ASIC4. The ASICs are in fact part of a larger superfamily termed degenerin/epithelial Na+ channels (DEG/ENaC) and share with it the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N- and C- termini.

Several lines of evidence indicate that ASIC3 may function as a pain sensor. First, it is specifically located in dorsal root ganglia (DRG) neurons and in nociceptors that are involved in pain detection and transmission. In addition, in conditions such as inflammation and cardiac ischemia that include tissue acidosis and thus pain, ASIC3 currents have been detected. Finally, ASIC3 deficient mice display altered sensitivity to high intensity pain produced by heat or acid.

Interestingly, while in rats ASIC3 is expressed almost exclusively in DRG neurons, in humans its expression is more widespread suggesting a more extensive role in human nociception.

References
  1. Kellenberger, S. and Schild, L. (2002) Physiol. Rev. 82, 735.
  2. Chen, C. Cet al. (2002) Proc. Natl. Acad. Sci. U.S.A99, 8992.
  3. Price, M.Pet al. (2001) Neuron 32, 1071.
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