|Product Name||Cat #||Size|
|ASC-018||1 x 0.2 ml|
Guinea pig Anti-ASIC3
|AGP-052||1 x 0.2 ml|
Anti-pan ASIC (extracellular)
|ASC-031||1 x 0.2 ml|
ASIC3 Channel Overexpressed Membrane Fractions
|LX-100||2 x 0.1 ml|
|G-165||1 x 50 mg|
|STA-160||1 x 0.1 mg|
|STC-174||1 x 0.5 mg|
|STC-170||1 x 0.5 mg|
|STC-172||1 x 0.5 mg|
- Lyophilized Powder Lyophilized Powder
This product is freeze dried. All water molecules have been removed.
- Antigen Incl. Control Antigen Included
This antibody is shipped with its antigen FREE of charge!
- Bioassay Tested Bioassay Tested
This antibody has undergone quality control and has been approved by our professional team.
- QC Tested QC Tested
The activity of this product has been verified and approved by our professional team.
- Shipped at Room Temp. Shipped at Room Temp.
This lyophilized product is shipped at room temperature. Please see its certificate of analysis for further storage instructions.
- Live Cell Imaging Live Cell Imaging
This product has been tested in living cells.
- Immuno-Colocalization Immuno-Colocalization
This product is ideal for immuno-colocalization experiments. Secondary antibodies are not needed for conjugated antibodies!
- 100% Net Peptide 100% Net Peptide
This vial contains 100% net peptide content.
Alomone Labs is pleased to offer the ASIC3 Channel Premium Research Pack (#ESP-201). The Research Pack contains all you need for ASIC3 channel research: Antibodies recognizing different domains of the channel, membrane lysates expressing ASIC3 channel- your ideal control for western blot analysis and specific ASIC3 channel activator and blocker, all in one economical package!
ASIC3 is a member of a family of Na+ channels that are activated by external protons. The family includes another three members ASIC1, ASIC2 and ASIC4. The ASICs are in fact part of a larger superfamily termed degenerin/epithelial Na+ channels (DEG/ENaC) and share with it the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N- and C- termini.
Several lines of evidence indicate that ASIC3 may function as a pain sensor. First, it is specifically located in dorsal root ganglia (DRG) neurons and in nociceptors that are involved in pain detection and transmission. In addition, in conditions such as inflammation and cardiac ischemia that include tissue acidosis and thus pain, ASIC3 currents have been detected. Finally, ASIC3 deficient mice display altered sensitivity to high intensity pain produced by heat or acid.
Interestingly, while in rats ASIC3 is expressed almost exclusively in DRG neurons, in humans its expression is more widespread suggesting a more extensive role in human nociception.