KCa2-Related Channel Modulator Explorer Kit

A Screening Package of KCa2 Channel Modulators Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
Cat #: EK-122
Sizes: 9 Vials
Last update: 25/09/2019

Alomone Labs is pleased to offer the KCa2 Channel Modulator Explorer Kit (#EK-122). The Explorer Kit contains KCa2 blockers and openers ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Apamin
STA-200 1 x 0.1 mg
CyPPA
C-110 1 x 5 mg
1-EBIO
E-150 1 x 10 mg
NS-309
N-180 1 x 5 mg
NS-4591
N-325 1 x 5 mg
NS8593 hydrochloride
N-195 1 x 5 mg
Scyllatoxin
STS-370 1 x 50 µg
SKA-31
S-120 1 x 5 mg
Tamapin
STT-400 1 x 50 µg
References
    • KCa2 channels are extremely sensitive to the levels of intracellular Ca2+ and concentrations as low as 300-700 nM can open these channels very rapidly (5-15 ms). Hence, the KCa2 channels are highly sensitive and fast Ca2+ sensors, resembling other known Ca2+-binding proteins. This type of Ca2+-dependent activation is achieved by the constitutive binding of the KCa2 channels to calmodulin, a highly expressed Ca2+-binding protein via a calmodulin-binding domain situated at the cytoplasmic C-terminus.

      Pharmacologically, the KCa2 channels are the only known targets of the bee venom toxin Apamin, with KCa2.1 being the less sensitive, KCa2.2 the most sensitive and KCa2.3 showing intermediate sensitivity.

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