Compounds
| Product Name | Cat # | Size |
|---|---|---|
1-EBIO | E-150 | 1 x 10 mg |
Maurotoxin | STM-340 | 1 x 0.1 mg |
NS-309 | N-180 | 1 x 5 mg |
NS-4591 | N-325 | 1 x 5 mg |
NS-6180 | N-230 | 1 x 5 mg |
OsK-1 Toxin | STO-150 | 1 x 0.1 mg |
SKA-31 | S-120 | 1 x 5 mg |
TRAM 34 | T-105 | 1 x 5 mg |
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Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.
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Bioassay Tested Bioassay TestedThis antibody has undergone quality control and has been approved by our professional team.
Sizes: 8 Vials
Last update: 11/06/2019
Alomone Labs is pleased to offer the KCNN4 (KCa3.1, SK4) Channel Modulator Explorer Kit (#EK-133). The Explorer Kit contains KCNN4 blockers and openers ideal for screening purposes.
For research purposes only, not for human use
References
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KCa3.1 is part of the Ca2+ activated K+ channel family, whose members share the characteristic of being activated by intracellular Ca2+. The channel has an intermediate conductance, is voltage insensitive and is activated by Ca2+ in the submicromolar range. The channel has a similar topology to that of KV channels, that is, six transmembrane domains and intracellular N- and C-termini.
The functional role of the channel is to set the cell membrane potential at negative values so as to aid in the electrochemical transport of other ions such as Cl- and Ca2+. Indeed, KCa3.1 has a key role in sustaining the Ca2+ influx in activated T lymphocytes and in regulating Cl- secretion from colon epithelium. Therefore, specific blockers of the KCa3.1 channel have been proposed for the treatment of several diseases including autoimmune diseases, secretory diarrhea and sickle cell anemia.
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- Hoffman, J.F. et al. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 7366.
- Ghanshani, S. et al. (2000) J. Biol. Chem. 275, 37137.