This product has recently been released.
This product is freeze dried. All water molecules have been removed.
The activity of this product has been verified and approved by our professional team.
- Rosso, J.P. et al. (2015) Proc. Natl. Acad. Sci. U.S.A. 112, E891.
MmTX2 (Micrurotoxin 2) is a peptide toxin originally isolated from Micrurus mipartitus (Red-tailed coral snake) venom. The toxin is an allosteric modulator of γ-aminobutyric acid type A receptors and tightly binds to these receptors at subnanomolar concentrations. MmTX2 allosterically increases GABA(A) receptor susceptibility to agonistic actions1. Like MmTX1 (#STM-550), MmTX2 may be a priceless tool in evoking seizures for testing novel antiepileptic drugs or as lead molecules for designing therapeutics that modulate GABA(A) receptor activity1.
GABA(A) receptors belong to the cys-loop pentameric ligand-gated ion channel family. These receptors are major inhibitory neurotransmitter receptors in the brain and in the mammalian central nervous system and are responsible for the mediation of GABA action, a major inhibitory neurotransmitter, through the central nervous system2.
MmTX2 (#STM-600) is a highly pure, synthetic, and biologically active peptide toxin.