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- Khom, S. et al. (2006) Mol. Pharmacol. 69, 640.
- Williams, M. et al. (1989) J. Pharmacol. Exp. Ther. 248, 89.
- Bennett, D.A. (1987) Physiol. Behav. 41, 241.
- Williams, M. et al. (1989) J. Pharmacol. Exp. Ther. 248, 89.
- Atack, J.R. (2003) Curr. Drug Targets CNS Neurol. Disord. 2, 213.
- Pomara, N. et al. (2015) Prog Neuropsychopharmacol. Biol. Psychiatry 56, 35.
CGS 20625 is a synthetic compound that acts as a potent and selective partial agonist of GABA(A) receptors.
CGS 20625 is a pyrazolopyridine compound that possesses anxiolytic and anticonvulsant characteristics. It binds to a specific recognition site on GABAA receptors containing α1, α2, α3, and α5 subunits1-3.
GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA actions, a major inhibitory neurotransmitter, throughout the central nervous system where it plays an important role in inhibiting cell excitation. GABA(A) receptors are a major target for antiseizure drugs4.
CGS 20625 (#C-390) is a highly pure, synthetic, and biologically active compound.
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Antibodies
- Anti-GABA(A) α1 Receptor (extracellular) Antibody (#AGA-001)
- Anti-GABA(A) α1 Receptor (extracellular)-ATTO Fluor-488 Antibody (#AGA-001-AG)
- Guinea pig Anti-GABA(A) α1 Receptor (extracellular) Antibody (#AGA-001-GP (formerly AGP-083))
- Anti-GABA(A) α2 Receptor Antibody (#AGA-002)
- Anti-GABA(A) α3 Receptor (extracellular) Antibody (#AGA-003)
- Anti-GABA(A) α4 Receptor (extracellular) Antibody (#AGA-008)
- Anti-GABA(A) α6 Receptor (extracellular) Antibody (#AGA-004)
- Anti-GABA(A) γ2 Receptor (extracellular) Antibody (#AGA-005)
- Anti-GABA(A) δ Receptor (extracellular) Antibody (#AGA-014)
- Anti-GABA(A) ρ1 Receptor (GABRR1) (extracellular) Antibody (#AGA-006)
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