Name: CGS 20625
Brand: Alomone Labs
SKU: C-390
Availability: InStock

Cat #: C-390

Lyophilized Powder yes

Bioassay Tested

Source Synthetic

MW: 309.36

Purity: >99%

Effective concentration 1-100 µM.

Structure

Chemical name 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one.

Molecular formula C₁₈H₁₉N₃O₂.

CAS No.: 111205-55-1

PubChem CID 163844

Activity CGS 20625 acts as a partial agonist at GABA(A) receptors (EC₅₀ = 11.2-23.7 µM)¹. It is a potent and selective non-benzodiazepine ligand at the central benzodiazepine receptor (IC₅₀ = 1.3 nM), with anxiolytic and anticonvulsant effects in vivo².

References-Activity

Khom, S. et al. (2006) Mol. Pharmacol. 69, 640.
Williams, M. et al. (1989) J. Pharmacol. Exp. Ther. 248, 89.

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.

Solubility Soluble in DMSO and ethanol. Centrifuge before use (10000 x g, 5 min).

Storage of solutions Up to three months at -20°C.

Our bioassay

Alomone Labs CGS 20625 activates GABA(A) receptors expressed in Xenopus oocytes.
Representative time course of GABA(A) α1/β2 receptor current, activated by 10 µM and 100 µM CGS 20625 (#C-390), as indicated (bars), at a holding potential of -60 mV.

References - Scientific background

Bennett, D.A. (1987) Physiol. Behav. 41, 241.
Williams, M. et al. (1989) J. Pharmacol. Exp. Ther. 248, 89.
Atack, J.R. (2003) Curr. Drug Targets CNS Neurol. Disord. 2, 213.
Pomara, N. et al. (2015) Prog Neuropsychopharmacol. Biol. Psychiatry 56, 35.

Scientific background

CGS 20625 is a synthetic compound that acts as a potent and selective partial agonist of GABA(A) receptors.

CGS 20625 is a pyrazolopyridine compound that possesses anxiolytic and anticonvulsant characteristics. It binds to a specific recognition site on GABA_A receptors containing α1, α2, α3, and α5 subunits^1-3.

GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA actions, a major inhibitory neurotransmitter, throughout the central nervous system where it plays an important role in inhibiting cell excitation. GABA(A) receptors are a major target for antiseizure drugs⁴_.

Target GABA(A) receptors

Lyophilized Powder

Last update: 02/03/2021

CGS 20625 (#C-390) is a highly pure, synthetic, and biologically active compound.

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