Muscimol hydrobromide

Agarin hydrobromide
A Potent Agonist of GABA(A) Receptor and a Partial Agonist of GABA(A) ρ Receptor
    Cat #: M-240
    Alternative Name Agarin hydrobromide
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 195.01
    Purity: >96% (HPLC)
    Effective concentration 0.01-1 µM.
      • Muscimol hydrobromide
    Chemical name 5-(aminomethyl)-1,2-oxazol-3-one; hydrobromide.
    Molecular formula C4H7BrN2O2.
    CAS No.: 18174-72-6.
    PubChem CID 205536
    Activity Muscimol is a potent GABAA receptor agonist (EC50 of 0.92, 0.62 and 0.20 µM on α1/β3/γ2, α4/β3/γ2 and α4/β3/δ, respectively)1. It is also a partial agonist at GABAA-ρ receptor (EC50 of 3 µM on human homopentameric ρ1 receptor)2.
      • Mortensen, M. et al. (2010) J. Physiol. 588, 1251.
      • Wang, J. et al. (2007) J. Biol. Chem. 282, 26210.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Up to 200 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
      • Muscimol hydrobromide
        Alomone Labs Muscimol hydrobromide activates GABA(A) receptors expressed in Xenopus oocytes.
        Time course of GABA(A) α1/β2 currents, reversibly activated in a concentration dependent manner by 0.01 µM, 0.1 µM and 1 µM Muscimol hydrobromide (#M-240) while membrane potential was held at -60 mV.
    References - Scientific background
      • Muscimol (also known as Agarin) is a potent and selective GABA(A) receptor agonist and a partial agonist of GABA(C) receptor1,2. It activates the receptors through a structural transition from the closed to the open state. Muscimol demonstrates potency with EC50 values of 0.92 µM on α1/β3/γ2 receptor and 0.20 µM on α4/β/3δ receptor2.

        The compound is extracted from the mushroom Amanita muscaria as a psychotropic drug and is being used as a local anesthetic drug. Studies have shown the effectiveness of muscimol for reduction of neuropathic pain symptoms1.

        GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate the actions of GABA, a major inhibitory neurotransmitter, in the central nervous system. The GABA(A) receptor is considered to be a major target of antiseizure drugs1,3.

    Target GABA(A) receptors
    Last update: 23/07/2019

    Muscimol hydrobromide (#M-240) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Citations
    Related Products