
This product is freeze dried. All water molecules have been removed.

Every lot is tried & tested in a relevant biological assay.
Our Bioassay
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- Mortensen, M. et al. (2010) J. Physiol. 588, 1251.
- Wang, J. et al. (2007) J. Biol. Chem. 282, 26210.
- Alomone Labs Muscimol hydrobromide activates GABA(A) receptors expressed in Xenopus oocytes.Time course of GABA(A) α1/β2 currents, reversibly activated in a concentration dependent manner by 0.01 µM, 0.1 µM and 1 µM Muscimol hydrobromide (#M-240) while membrane potential was held at -60 mV.
- 1. Hosseini, M. et al. (2014) Emerg. (Tehran) 2, 151.
- 2. Mortensen, M. et al. (2010) J. Physiol. 588, 1251.
- 3. Nohria, V. and Giller, E. (2007) Neurotherapeutics 4, 102.
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Muscimol (also known as Agarin) is a potent and selective GABA(A) receptor agonist and a partial agonist of GABA(C) receptor1,2. It activates the receptors through a structural transition from the closed to the open state. Muscimol demonstrates potency with EC50 values of 0.92 µM on α1/β3/γ2 receptor and 0.20 µM on α4/β/3δ receptor2.
The compound is extracted from the mushroom Amanita muscaria as a psychotropic drug and is being used as a local anesthetic drug. Studies have shown the effectiveness of muscimol for reduction of neuropathic pain symptoms1.
GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate the actions of GABA, a major inhibitory neurotransmitter, in the central nervous system. The GABA(A) receptor is considered to be a major target of antiseizure drugs1,3.
Muscimol hydrobromide (#M-240) is a highly pure, synthetic, and biologically active compound.
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- Anti-GABA(A) α1 Receptor (extracellular) Antibody (#AGA-001)
- Anti-GABA(A) α1 Receptor (extracellular)-ATTO-488 Antibody (#AGA-001-AG)
- Anti-GABA(A) α2 Receptor Antibody (#AGA-002)
- Anti-GABA(A) α3 Receptor (extracellular) Antibody (#AGA-003)
- Anti-GABA(A) α4 Receptor (extracellular) Antibody (#AGA-008)
- Anti-GABA(A) α6 Receptor (extracellular) Antibody (#AGA-004)
- Anti-GABA(A) γ2 Receptor (extracellular) Antibody (#AGA-005)
- Anti-GABA(A) δ Receptor (extracellular) Antibody (#AGA-014)
- Anti-GABA(A) ρ1 Receptor (GABRR1) (extracellular) Antibody (#AGA-006)
- Anti-GABA(A) ρ2 Receptor (GABRR2) (extracellular) Antibody (#AGA-007)
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