Every lot is tried & tested in a relevant biological assay.
Our Bioassay
- Mortensen, M. et al. (2010) J. Physiol. 588, 1251.
- Wang, J. et al. (2007) J. Biol. Chem. 282, 26210.
- Hosseini, M. et al. (2014) Emerg. (Tehran) 2, 151.
- Mortensen, M. et al. (2010) J. Physiol. 588, 1251.
- Nohria, V. and Giller, E. (2007) Neurotherapeutics 4, 102.
Muscimol (also known as Agarin) is a potent and selective GABA(A) receptor agonist and a partial agonist of GABA(C) receptor1,2. It activates the receptors through a structural transition from the closed to the open state. Muscimol demonstrates potency with EC50 values of 0.92 µM on α1/β3/γ2 receptor and 0.20 µM on α4/β/3δ receptor2.
The compound is extracted from the mushroom Amanita muscaria as a psychotropic drug and is being used as a local anesthetic drug. Studies have shown the effectiveness of muscimol for reduction of neuropathic pain symptoms1.
GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate the actions of GABA, a major inhibitory neurotransmitter, in the central nervous system. The GABA(A) receptor is considered to be a major target of antiseizure drugs1,3.
Muscimol hydrobromide (#M-240) is a highly pure, synthetic, and biologically active compound.
Applications
Citations
Specifications
Scientific Background
Related Products
Antibodies
- Anti-GABA(A) α1 Receptor (extracellular) Antibody (#AGA-001)
- Anti-GABA(A) α1 Receptor (extracellular)-ATTO Fluor-488 Antibody (#AGA-001-AG)
- Anti-GABA(A) α2 Receptor Antibody (#AGA-002)
- Anti-GABA(A) α3 Receptor (extracellular) Antibody (#AGA-003)
- Anti-GABA(A) α4 Receptor (extracellular) Antibody (#AGA-008)
- Anti-GABA(A) α6 Receptor (extracellular) Antibody (#AGA-004)
- Anti-GABA(A) γ2 Receptor (extracellular) Antibody (#AGA-005)
- Anti-GABA(A) δ Receptor (extracellular) Antibody (#AGA-014)
- Anti-GABA(A) ρ1 Receptor (GABRR1) (extracellular) Antibody (#AGA-006)
- Anti-GABA(A) ρ2 Receptor (GABRR2) (extracellular) Antibody (#AGA-007)
Pharmacological tools
Explorer kits & Research packs
Need Help With This Product?
Our reagent specialists are here to help you find the best product for your application. Please call or email us and we will be happy to help you find the right product for the job.
Call us at
+972 2587 2202 or Email Us