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Novokinin

An Agonist of Angiotensin II Receptors

Cat #: SPA-125
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Synthetic peptide
    MW: 796 Da
    Purity: ≥98% (HPLC)
    Effective concentration 1-10 µM.
    Sequence RPLKPW.
    Structure
    Molecular formula C39H61N11O7.
    CAS No.: 358738-77-9
    Activity An Angiotensin II Receptor Agonist1.
    References-Activity
    1. Yamada, Y. et al. (2008) Biosci. Biotechnol. Biochem. 72, 257.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in water. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Novokinin activates AT1R expressed in CHO-K1-mt Aequorin-Gα16 cells.
      Alomone Labs Novokinin activates AT1R expressed in CHO-K1-mt Aequorin-Gα16 cells.
      Ca2+ response was detected by measuring aequorin-derived fluorescence following application of Novokinin (#SPA-125) and Angiotensin II (#GPA-100) at different concentrations. 10 nM Angiotensin II activates ~100% of the AT1R, 1 mM Novokinin activates ~110% of the AT1R.
    References - Scientific background
    1. Yamada, Y. et al. (2008) Biosci. Biotechnol. Biochem. 72, 257.
    2. Ohinata, K. et al. (2009) Peptides 30, 1105.
    3. Yamada, Y. et al. (2009) Peptides 30, 735.
    Scientific background Novokinin is a potent hypotensive peptide with high affinity (Ki=7.35 µM) as an agonist for angiotensin II (Ang II) receptors. Novokinin was designed based on a structure of ovokinin, a vasorelaxing peptide derivative of ovalbumin. Novokinin was shown to have vasorelaxing activity in the mesenteric artery isolated from spontaneously hypertensive rats. It has the ability to reduce systolic blood pressure after oral administration1. Studies show that orally and intracerebroventricularly administration of novokinin has the ability to suppress food intake in mice2. In addition, the compound demonstrates inhibitory antinociceptive effects of morphine in mice3.
    Target Angiotensin II receptors
    Peptide Content: 100%
    Lyophilized Powder
    Last update: 12/08/2021

    Novokinin (#SPA-125) is a highly pure, synthetic, and biologically active peptide.

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    For research purposes only, not for human use
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