An Activator of TRPV1 Channels
    Cat #: P-205
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 391.3
    Purity: 100%
    Form Lyophilized powder.
    Effective concentration 5 nM - 5 µM.
    • Palvanil
    Chemical name N-(4-hydroxy-3-methoxybenzyl)palmitamide.
    Molecular formula C24H41NO3.
    CAS No.: 69693-13-6.
    Activity Palvanil activates TRPV1 channels at 100 nM in a slower manner than capsaicin1.
    1. De Petrocellis, L. et al. (2011) Pharmacol. Res. 63, 294.
    2. Kort, M.E. and Kym, P.R. (2012) Prog. Med. Chem. 51, 57.
    3. Luongo, L. et al. (2012) Pharmacol. Res. 66, 243.
    4. Peppin, J.F. and Pappagallo, M. (2014) Ther. Adv. Neurol. Disord. 7, 22.
    5. Rossi, F. et al. (2014) Br. J. Pharmacol. 171, 2621.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO 10 mM. Centrifuge all product preparations before use (10000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Palvanil
      Alomone Labs Palvanil activates TRPV1 channels heterologously expressed in C6 cells. 
      Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+ were measured. Normalized fluorescence before (control, gray dotted line) and after application of 0.1 and 1 µM Palvanil (#P-205), (as indicated).
    References - Scientific background
    1. Kort, M.E. and Kym, P.R. (2012) Prog. Med. Chem. 51, 57.
    2. Luongo, L. et al. (2012) Pharmacol. Res. 66, 243.
    3. Peppin, J.F. and Pappagallo, M. (2014) Ther. Adv. Neurol. Disord. 7, 22.
    4. Rossi, F. et al. (2014) Br. J. Pharmacol. 171, 2621.
    Scientific background

    Transient receptor potential vanilloid receptor 1 (TRPV1) is a non-selective cation channel that is stimulated by capsaicin, protons, endogenous lipids, and hot temperature. Upon activation, TRPV1 initiates a signaling cascade that results in elevated levels of pain-inducing factors. It is located in sensory ganglia composed of neurons that send projection throughout the periphery1.

    N-palmitoyl-vanillamide (palvanil) is a TRPV1 agonist, a non-poignant analogue to capsaicin (capsaicinoid). It has a slower kinetic opening-onset than capsaicin, but it activates the channel more potently. It induces significantly milder side effects – e.g. imbalanced thermal homeostasis and bronchoconstriction - than capsaicin, and it seems to be suitable as a topical anti-analgesic. It is effective in reducing edema2, and can inhibit inflammatory and neuropathic pain3, and interestingly, in vitro data have shown that at low concentrations it encourages the proliferation of osteoclasts, and does the opposite at high concentrations4.

    Target TRPV1 channels
    Last update: 24/01/2020

    Palvanil (#P-205) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
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