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Resiniferatoxin

RTX
A Potent and Selective Activator of TRPV1 Channel
Cat #: R-400
Alternative Name RTX
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Euphorbia resinifera (Moroccan cactus).
    Source Natural
    MW: 628.72
    Purity: 95-98% (HPLC)
    Effective concentration 20 nM - 1 µM.
    Structure
    Chemical name 4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)- 3a,3b,6,6a,9a,10,11,11aoctahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9 b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneaceta.
    Molecular formula C37H40O9.
    CAS No.: 57444-62-9
    Activity Resiniferatoxin is a potent and selective activator of the TRPV1 (Vanilloid/Capsaicin receptor 1) channel1.
    References-Activity
    1. Szallasi, A. and Blumberg, P.M. (1989) Neuroscience 30, 515.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Methanol or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two week at 4°C or six months at -20°C.
    Our bioassay
    • Alomone Labs Resiniferatoxin induces Ca2+ influx via activation of TRPV1 expressed in HEK293 cells.
      Alomone Labs Resiniferatoxin induces Ca2+ influx via activation of TRPV1 expressed in HEK293 cells.
      Cells were loaded with 1mM fluo-3 AM and then stimulated with Resiniferatoxin (#R-400). The left panel shows the intracellular Ca2+ levels 10 sec post stimulation with different concentrations of Resiniferatoxin plotted against drug concentration (ED50 = 2 µM) . The right panel shows cytoplasmic Ca2+ before and after stimulation of cells with 10 µM Resiniferatoxin.
    References - Scientific background
    1. Szallasi, A. and Blumberg, P.M. (1989) Neuroscience 30, 515.
    2. Raisinghani, M. et al. (2005) J. Physiol. 567, 771.
    Scientific background

    Resiniferatoxin is a potent and selective agonist of the TRPV1 (Vanilloid/Capsaicin receptor) channel.1 Application of sub-nanomolar concentrations of Resiniferatoxin irreversibly induces a sustained slow current and depolarization in DRG neurons.2

    Treatment of rats with Resiniferatoxin, like treatment with capsaicin, causes hypothermia, neurogenic inflammation and pain. These responses were followed by a loss of thermoregulation, by desensitization to neurogenic inflammation and by chemical and thermal analgesia, with a cross-tolerance between Resiniferatoxin and capsaicin.1

    Target TRPV1 channels
    Lyophilized Powder
    Last update: 06/01/2021

    Resiniferatoxin (#R-400) is a highly pure, natural, and biologically active compound.

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    For research purposes only, not for human use

    Applications

    Specifications

    Scientific Background

    Citations

    Citations
    in vivo
    1. Mouse (intraganglionar injections).
      Gomes, L.O. et al. (2018) J. Pharm. Pharmacol. 70, 893.
    2. Rat (intrathecal injections).
      Leo, M. et al. (2017) Mediators Inflamm. 2017, 2786427.
    Product citations
    1. Tsumura, M. et al. (2012) Cell. Calcium. 52, 124.

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    Shipping and Ordering information

    Resources

    Contribution of Ion Channels in Pain Sensation

    The Transient Receptor Potential (TRP) Ion Channels

    Ion Channels and Pain

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