Every lot is tried & tested in a relevant biological assay.
Our Bioassay
- Szallasi, A. and Blumberg, P.M. (1989) Neuroscience 30, 515.
- Alomone Labs Resiniferatoxin induces Ca2+ influx via activation of TRPV1 expressed in HEK293 cells.Cells were loaded with 1mM fluo-3 AM and then stimulated with Resiniferatoxin (#R-400). The left panel shows the intracellular Ca2+ levels 10 sec post stimulation with different concentrations of Resiniferatoxin plotted against drug concentration (ED50 = 2 µM) . The right panel shows cytoplasmic Ca2+ before and after stimulation of cells with 10 µM Resiniferatoxin.
- Szallasi, A. and Blumberg, P.M. (1989) Neuroscience 30, 515.
- Raisinghani, M. et al. (2005) J. Physiol. 567, 771.
Resiniferatoxin is a potent and selective agonist of the TRPV1 (Vanilloid/Capsaicin receptor) channel.1 Application of sub-nanomolar concentrations of Resiniferatoxin irreversibly induces a sustained slow current and depolarization in DRG neurons.2
Treatment of rats with Resiniferatoxin, like treatment with capsaicin, causes hypothermia, neurogenic inflammation and pain. These responses were followed by a loss of thermoregulation, by desensitization to neurogenic inflammation and by chemical and thermal analgesia, with a cross-tolerance between Resiniferatoxin and capsaicin.1
Resiniferatoxin (#R-400) is a highly pure, natural, and biologically active compound.
Applications
Citations
- Mouse (intraganglionar injections).
Gomes, L.O. et al. (2018) J. Pharm. Pharmacol. 70, 893. - Rat (intrathecal injections).
Leo, M. et al. (2017) Mediators Inflamm. 2017, 2786427.
- Tsumura, M. et al. (2012) Cell. Calcium. 52, 124.
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