A Potent and Partial Blocker of TRPV1 Channel
    Cat #: I-800
    Alternative Name 5'-IRTX
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Euphorbia resinifera (Moroccan cactus).
    Source Semi-synthetic
    MW: 754.6
    Purity: >99%
    Effective concentration 100 nM - 10 µM.
    • 5'-Iodoresiniferatoxin
    Chemical name 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(pheny lmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzene acetate).
    Molecular formula C37H39IO9.
    CAS No.: 535974-91-5.
    Activity 5'-Iodoresiniferatoxin is a potent and partial blocker of TRPV1 (Vanilloid/Capsaicin receptor 1) channel1. It also abolishes the inhibitory effect of capsaicin on CaV currents in DRG neurons2.
    1. Wahl, P. et al. (2001) Mol. Pharmacol59, 9.
    2. Wu, Z.Z. et al. (2005) J. Biol. Chem280, 18142.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or six months at -20°C.
    Protect from light.
    Our bioassay
    • 5'-Iodoresiniferatoxin
      Alomone Labs 5'-Iodoresiniferatoxin inhibits Capsaicin induced Ca2+ influx via the activation of TRPV1 expressed in HEK-293 cells.
      Cells were loaded with 1 mM fluo-3 AM and then stimulated with 10 µM capsaicin in the absence (blue) or presence (purple) of 100 nM and 200 nM (green) 5'-Iodoresiniferatoxin (#I-800). The figure shows intracellular Ca2+ levels before and after stimulation of cells with 10 µM capsaicin.
    References - Scientific background
    1. Wahl, P. et al. (2001) Mol. Pharmacol59, 9.
    2. Wu, Z.Z. et al. (2005) J. Biol. Chem280, 18142.
    Scientific background 5’-Iodoresiniferatoxin (5’-IRTX) is a potent and partial antagonist of the TRPV1 (Vanilloid/capsaicin receptor) channel.1 It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). 5’-Iodoresiniferatoxin partially blocked capsaicin-induced currents in Xenopus oocytes expressing TRPV1 channels (IC50 = 3.9 nM).1 5’-Iodoresiniferatoxin abolished an inhibitory effect of capsaicin on CaV currents (probably mediated by TRPV1) in DRG neurons.
    Target TRPV1 channels
    Last update: 24/01/2020

    5’-Iodoresiniferatoxin (#I-800) is a highly pure, semi-synthetic, and biologically active compound.

    For research purposes only, not for human use
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