A Potent and Partial Blocker of TRPV1 Channel
    Cat #: I-800
    Alternative Name 5'-IRTX
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Euphorbia resinifera (Moroccan cactus).
    Source Semi-synthetic
    MW: 754.6
    Purity: >99%
    Effective concentration 100 nM - 10 µM.
      • 5'-Iodoresiniferatoxin
    Chemical name 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(pheny lmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzene acetate).
    Molecular formula C37H39IO9.
    CAS No.: 535974-91-5.
    Activity 5'-Iodoresiniferatoxin is a potent and partial blocker of TRPV1 (Vanilloid/Capsaicin receptor 1) channel1. It also abolishes the inhibitory effect of capsaicin on CaV currents in DRG neurons2.
      • Wahl, P. et al. (2001) Mol. Pharmacol59, 9.
      • Wu, Z.Z. et al. (2005) J. Biol. Chem280, 18142.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or six months at -20°C.
    Protect from light.
      • 5'-Iodoresiniferatoxin
        Alomone Labs 5'-Iodoresiniferatoxin inhibits Capsaicin induced Ca2+ influx via the activation of TRPV1 expressed in HEK-293 cells.
        Cells were loaded with 1 mM fluo-3 AM and then stimulated with 10 µM capsaicin in the absence (blue) or presence (purple) of 100 nM and 200 nM (green) 5'-Iodoresiniferatoxin (#I-800). The figure shows intracellular Ca2+ levels before and after stimulation of cells with 10 µM capsaicin.
    References - Scientific background
    • 1. Wahl, P. et al. (2001) Mol. Pharmacol59, 9.
    • 2. Wu, Z.Z. et al. (2005) J. Biol. Chem280, 18142.
      • 5’-Iodoresiniferatoxin (5’-IRTX) is a potent and partial antagonist of the TRPV1 (Vanilloid/capsaicin receptor) channel.1 It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). 5’-Iodoresiniferatoxin partially blocked capsaicin-induced currents in Xenopus oocytes expressing TRPV1 channels (IC50 = 3.9 nM).1 5’-Iodoresiniferatoxin abolished an inhibitory effect of capsaicin on CaV currents (probably mediated by TRPV1) in DRG neurons.
    Target TRPV1 channels
    Last update: 18/11/2019

    5’-Iodoresiniferatoxin (#I-800) is a highly pure, semi-synthetic, and biologically active compound.

    For research purposes only, not for human use