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TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1
According to IUPHAR the TRP family comprises three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family; the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5
TRPV1 channel has many activators; among them heat, protons, vanilloids like capsaicin, resiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.6,7 TRPV1 is expressed predominantly in nociceptors and in sensory neurons.
Recent studies demonstrated involvement of TRPV1 in apoptosis where inhibition of the receptor prevented apoptosis.8,9
Species reactivity key:
Immuno-colocalization of TRPV1 and mGluR5 in rat DRGImmunohistochemical staining of rat dorsal root ganglion using Anti-Rat TRPV1 (VR1) (extracellular)-ATTO-488 Antibody (#ACC-029-AG), (1:60) and Anti-mGluR5 (extracellular)-ATTO-594 Antibody (#AGC-007-AR), (1:60). A. TRPV1 staining (green). B. mGluR5 staining of the same section (red). C. Merge of A and B demonstrates co-localization of TRPV1 and mGluR5 in DRG cells. Nuclei were stained using DAPI as the counterstain (blue).
Anti-Rat TRPV1 (VR1) (extracellular) Antibody (#ACC-029) is a highly specific antibody directed against an extracellular epitope of the rat TRPV1 channel. The antibody can be used in western blot, immunohistochemistry, and live cell imaging applications. It has been designed to recognize TRPV1 from rat samples only.
Anti-Rat-TRPV1 (VR1) (extracellular)-ATTO-488 Antibody (#ACC-029-AG) is directly labeled with an ATTO-488 fluorescent dye. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The ATTO-488 label is analogous to the well known dye fluorescein isothiocyanate (FITC) and can be used with filters typically used to detect FITC. Anti-Rat-TRPV1 (VR1) (extracellular)-ATTO-488 Antibody has been tested in immunohistochemical and live cell imaging applications and is specially suited to experiments requiring simultaneous labeling of different markers.
Antibodies for live cell imaging experiments
- Anti-Rat TRPV1 (VR1) (extracellular) Antibody (#ACC-029). This antibody recognizes a an extracellular epitope and can be used to detect TRPV1 in live cells.
- Extracellular-Targeted TRPV Channel Antibody Explorer Kit (#AK-485)
- pH-Sensitive TRP Channel Antibody Explorer Kit (#AK-475)
- TRP Channel Antibodies for Pain Research Explorer Kit (#AK-370)
- TRPV1 Channel Activator Explorer Kit (#EK-115)
- TRPV1 Channel Blocker Explorer Kit (#EK-117)
- TRPV1 Channel Modulator Explorer Kit (#EK-114)