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Certificate of Analysis

  • Bioassay Tested

TRPV1 Channel Blocker Explorer Kit

A Screening Package of TRPV1 Channel Blockers Economically Priced

Cat #: EK-117
Size: 8 Vials
Form: Lyophilized

A 784168 Cat #: A-345

Size: 5 mg Source: Synthetic MW: 479.4 Purity: >99%
Effective concentration
10 nM - 1 µM.
Activity
A 784168 is a potent TRPV1 antagonist, inhibiting human TRPV1 activation by 50 nM capsaicin with IC50 of 25 nM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO or 50 mM in ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

A-889425 Cat #: A-195

Size: 1 mg Source: Synthetic MW: 425.4 Purity: >98% (HPLC)
Effective concentration
0.5 nM - 50 µM.
Activity
A-889425 blocks TRPV1 channels with an IC50 of 335 nM (rat) and 34 nM (human)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO up to 100 mM. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

AMG 9810 Cat #: A-180

Size: 5 mg Source: Synthetic MW: 337.4 Purity: >96% (HPLC)
Effective concentration
0.5 nM - 50 µM.
Activity
AMG 9810 blocks TRPV1 with IC50 ~0.01 µM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Ethanol 50 mM. Centrifuge all product preparations before use (10 000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

BCTC Cat #: B-110

Size: 10 mg Source: Synthetic MW: 372.9 Purity: >99% (HPLC)
Effective concentration
1 nM – 100 nM.
Activity
BCTC is a potent and selective antagonist of TRPV1 channels, shown to inhibit capsaicin-, pH- and PKC-induced responses of mouse TRPV1 with IC50 of 1.3, 0.59 and 0.37 nM, respectively.1,2 BCTC is also a blocker of TRPM8 channels, inhibiting rat TRPM8-mediated menthol and cold-evoked Ca2+ response with IC50 of 0.6 µM.3
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
1-10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Capsazepine Cat #: C-120

Size: 5 mg Source: Synthetic MW: 376.9 Purity: >97%
Effective concentration
0.1-100 µM.
Activity
Capsazepine is a selective antagonist of the vanilloid VR1 receptor (TRPV1) with IC50 of 40 nM, and an activator of the ENaC channels.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

LASSBio-1135 Cat #: L-190

Size: 5 mg Source: Synthetic MW: 286.3 Purity: >99%
Effective concentration
0.1-100 µM.
Activity
LASSBio-1135 is a TRPV1 channel and a TNF-α receptor antagonist1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

SB-366791 Cat #: S-180

Size: 10 mg Source: Synthetic MW: 287.7 Purity: >99%
Effective concentration
5 nM - 50 µM.
Activity
SB-366791 is a TRPV1 channel antagonist1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

SB-705498 Cat #: S-160

Size: 5 mg Source: Synthetic MW: 428.05 Purity: >99%
Effective concentration
10 nM - 50 µM.
Activity
SB-705498 is a potent orally active TRPV1 blocker1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO 100 mM. Centrifuge all product preparations before use (10000 x g 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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