TRPV Channel Antibody Explorer Kit

A Screening Package of TRPV Channel Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
  • Shipped at Room Temp.
Cat #: AK-211
Sizes: 24 Vials
Last update: 03/09/2018

Alomone Labs is pleased to offer the TRPV Channel Antibody Explorer Kit (#AK-211). This Explorer Kit includes antibodies directed to TRPV channels.

For research purposes only, not for human use
Compounds
Note Guinea pig polyclonal antibodies (#AGP-118 & #AGP-033) are included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 The TRP channels have putative six-transmembrane domains (TM) with a pore domain between the fifth and the sixth TM, and all assemble as tetramers. Both the N- and the C-terminus of all TRPs are intracellular.3

According to IUPHAR, the TRP family is comprised of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three additional subfamilies are also considered to belong to the TRP family: the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5

References
  1. Montell, C. et al. (2002) Mol. Cell. 9, 229.
  2. Clapham, D.E. (2003) Nature 426, 517.
  3. Moran, M.M. et al. (2004) Curr.Opin.Neurobiol14, 362.
  4. Clapham, D.E. et al. (2003) Pharmacol. Rev55, 591.
  5. Gunthorpe, M.J. et al. (2002) Trends Pharmacol. Sci23, 183.
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