Overview
Alomone Labs is pleased to offer the TRPV Channel Antibody Explorer Kit (#AK-211). This Explorer Kit includes antibodies directed to TRPV channels.
Compounds
Compounds
Product Name | Cat # | Size |
---|---|---|
Anti-TRPV1 (VR1) Antibody |
ACC-030 | 1 x 50 µl |
Guinea pig Anti-TRPV1 (VR1) Antibody |
AGP-118 | 1 x 50 µl |
Anti-Rat TRPV1 (VR1) (extracellular) Antibody |
ACC-029 | 1 x 50 µl |
Anti-TRPV2 (VRL1) Antibody |
ACC-032 | 1 x 50 µl |
Anti-TRPV2 (VRL1) (extracellular) Antibody |
ACC-039 | 1 x 50 µl |
Anti-Human TRPV2 (VRL1) (extracellular) Antibody |
ACC-139 | 1 x 50 µl |
Guinea pig Anti-TRPV2 (VRL1) (extracellular) Antibody |
AGP-033 | 1 x 50 µl |
Anti-TRPV3 (extracellular) Antibody |
ACC-033 | 1 x 50 µl |
Anti-TRPV4 Antibody |
ACC-034 | 1 x 50 µl |
Anti-TRPV4 (extracellular) Antibody |
ACC-124 | 1 x 50 µl |
Anti-TRPV5 Antibody |
ACC-035 | 1 x 50 µl |
Anti-TRPV6 Antibody |
ACC-036 | 1 x 50 µl |
Anti-Human TRPV6 (extracellular) Antibody |
ACC-028 | 1 x 50 µl |
Scientific Background
Scientific Background
TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 The TRP channels have putative six-transmembrane domains (TM) with a pore domain between the fifth and the sixth TM, and all assemble as tetramers. Both the N- and the C-terminus of all TRPs are intracellular.3
According to IUPHAR, the TRP family is comprised of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three additional subfamilies are also considered to belong to the TRP family: the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5
- Montell, C. et al. (2002) Mol. Cell. 9, 229.
- Clapham, D.E. (2003) Nature 426, 517.
- Moran, M.M. et al. (2004) Curr.Opin.Neurobiol. 14, 362.
- Clapham, D.E. et al. (2003) Pharmacol. Rev. 55, 591.
- Gunthorpe, M.J. et al. (2002) Trends Pharmacol. Sci. 23, 183.
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