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4-6. Anti-CaV1.3 (CACNA1D) (extracellular) Antibody, preincubated with the control peptide antigen.
All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptors. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous.1,2
The CaV1.3 channels are also expressed, as are other L-type channels, in neurons and neuroendocrine cells. However, accumulated data has shown the expression of CaV1.3 in heart and suggests that it plays a major role in the generation of cardiac pacemaker activity.3,4
Several peptidyl toxins have been described that are specific L-type channel blockers. These include the Mamba toxins Calcicludine (#SPC-650), Calciseptine (#C-500) and FS-2 (#F-700). So far no selective blocker for one of the CaV1 isoforms has been described.
Species reactivity key:
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of the rat protein. Anti-CaV1.3 (CACNA1D) (extracellular) Antibody (#ACC-311) can be used in western blot and immunohistochemistry and live cell imaging applications. It is specially suited to detect CaV1.3 channel in live cells. It has been designed to recognize CaV1.3 from mouse, rat and human samples.
Products for control experiments
- Anti-CaV1.3 (CACNA1D) Antibody (#ACC-005).
This antibody recognizes a different epitope and thus can also be used as a control for detecting CaV1.3.
- Guinea pig Anti-CaV1.3 (CACNA1D) Antibody (#AGP-061)
- Anti-CaV1.1 (extracellular) Antibody (#ACC-314)
- Anti-CaV1.2 (CACNA1C) Antibody (#ACC-003)
- Anti-CACNA2D2 (CaVα2δ2) (extracellular) Antibody (#ACC-102)
- Anti-CACNG6 (extracellular) Antibody (#ACC-112)
- Anti-CaBP1 Antibody (#ACS-002)
- Anti-Shank1 Antibody (#APZ-011)
- Blockers/Antagonists: peptides/peptide toxinsBlockers/Antagonists: small moleculesActivators/Agonists: small molecules