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2. Anti-DPP6 (extracellular) Antibody, preincubated with the control peptide antigen.
3-4. Anti-DPP6 (extracellular) Antibody, preincubated with the control peptide antigen.
- Lin, L. et al. (2014) J. Biol. Chem. pii: jbc.M114.578070.
- Jerng, H.H. and Pfaffinger, P.J. (2012) PLoS One 7, e38205.
- Busek, P. et al. (2004) Int. J. Biochem. Cell. Biol. 36, 408.
- Lin, L. et al. (2013) Nat. Commun. 4, 2270.
- Liao, C. et al. (2013) Eur. J. Med. Genet. 56, 484.
- Prontera, P. et al. (2014) Neurogenetics 15, 237.
- Chettier, R. et al. (2014) PLoS One 9, e103968.
Dipeptidyl-peptidase 6 (DPP6) is a type II membrane glycoprotein1 which is a part of the dipeptydil aminopeptidase-like proteins (DPPLs) subfamily. It is an auxiliary, glycoproteinic subunit of voltage dependent K+ channel 4 (KV4.x) that has a short cytoplasmic domain, a long extracellular domain and a transmembrane domain. It regulates sub-threshold, A-type K+ currents, and is important for the enhancement and localization of KV4.2 channels2.
DPPLs are a subgroup of the larger prolyl oligopeptidase family. A loss-of-function mutation at their enzymatic serine renders them incapable of cleaving peptides. Notable DPPLs include DPP8, DPP9, and DPPIV – the latter is known to regulate several key functions in varied systems, ranging from immune to CNS1,3.
Alternative mRNA splicing of the DPP6 gene (part of the di-genic DPLP group that also consists DPP10) gives rise to several isoforms that differ in their N-terminal (DPP6a, DPP6K, DPP6S, DPP6L DPP6E)4.
DPP6 proteins are widely expressed throughout both of the nervous systems – albeit much more predominantly in the CNS - and are known to play a major role in neurogenesis and neurodevelopment5.
Deletion mutations and haplo-insufficiency of the DPP6 gene has been shown to be associated with autism spectrum disorder, Gilles de la Tourette syndrome, dominant microcephaly and mental retardation5,6. Endometriosis – a condition characterized by extra-uteral endometrial glands that affects one tenth of fertile women population – has been linked with DPP6 in genome wide associations studies (GWASs)7.
Species reactivity key:
Anti–DPP6 (extracellular) Antibody (#APC-146) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the protein in living cells. It has been designed to recognize DPP6 from rat, mouse, and human samples.
Mouse brain sections.
Shiotani, H. et al. (2019) Mol. Cell. Neurosci. 94, 32.