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Certificate of Analysis

  • Bioassay Tested

ASIC Channel Modulator Explorer Kit

A Screening Package of ASIC Channel Modulators Economically Priced

Cat #: EK-113
Size: 10 Vials
Form: Lyophilized

MitTx Toxin Cat #: M-100

Size: 10 µg MW: 20.8 kDa (α subunit, 7.1 kDa and β subunit, 13.7 kDa) Purity: >98% (HPLC) Net peptide content: 100%
Origin
Natural protein isolated from Micrurus tener tener (Texas coral snake).
Effective concentration
20 nM
Activity
MitTx toxin activates ASIC1-containing channels1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Water or any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

APETx2 Cat #: STA-160

Size: 0.1 mg MW: 4561 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10 nM - 3 µM.
Activity
APETx2 inhibits ASIC3 channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or three months at -20°C.

Cono AIVGRPRF-amide Cat #: STC-174

Size: 0.5 mg MW: 914 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
50 µM.
Activity
Cono AIVGRPRF-amide is an ASIC3 channel positive modulator.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g for 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

Cono RPRF-amide Cat #: STC-170

Size: 0.5 mg MW: 574 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
50 µM.
Activity
Cono RPRF-amide is an ASIC3 channel positive modulator1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g for 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

Cono VGRPRF-amide Cat #: STC-172

Size: 0.5 mg MW: 730 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
50 µM.
Activity
Cono VGRPRF-amide is an ASIC3 channel positive modulator1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g for 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

GMQ Cat #: G-130

Size: 5 mg Source: Synthetic MW: 201.2 Purity: 99%
Effective concentration
1-5 mM.
Activity
GMQ is an ASIC modulator, ASIC3 opener and also induces an acidic shift of the pH dependence of inactivation of ASIC1a, -1b, -2a, and -31.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

GMQ hydrochloride Cat #: G-165

Size: 5 mg Source: Synthetic MW: 237.1 Purity: >99%
Effective concentration
1-5 mM.
Activity
GMQ is an ASIC modulator, an ASIC3 opener and also induces an acidic shift of the pH dependence of inactivation of ASIC1a, -1b, -2a, and -31.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Hm3a Toxin Cat #: STH-250

Size: 50 µg MW: 4287.1 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-200 nM.
Activity
Hm3a Toxin acts as a potent ASIC1a channel blocker with an IC50 value of 1-2 nM and ASIC1b channel activator with an EC50 value of 46.5 nM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g for 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

Mambalgin-3 Cat #: STM-500

Size: 50 µg MW: 6566 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10-50 nM.
Activity
A blocker of ASIC1-containing channels1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Store at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing.

Psalmotoxin-1 Cat #: STP-200

Size: 0.1 mg MW: 4689.5 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-10 nM.
Activity
Psalmotoxin-1 inhibits cation currents mediated by acid-sensing ion channels (ASIC1a)1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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