ASIC Channel Antibody Explorer Kit

A Screening Package of ASIC Channel Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-226
Sizes: 16 Vials
Last update: 23/04/2019

Alomone Labs is pleased to offer the ASIC Channel Antibody Explorer Kit (#AK-226). This Explorer Kit includes antibodies targeting ASIC channels along with their respective peptide control antigen. An ideal tool for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-ASIC1 Antibody
ASC-014 1 x 50 µl
Guinea pig Anti-ASIC1 Antibody
AGP-053 1 x 50 µl
Anti-ASIC2a Antibody
ASC-012 1 x 50 µl
Anti-ASIC3 Antibody
ASC-018 1 x 50 µl
Guinea pig Anti-ASIC3 Antibody
AGP-052 1 x 50 µl
Anti-ASIC4 Antibody
ASC-015 1 x 50 µl
Anti-ASIC5 (extracellular) Antibody
ASC-032 1 x 50 µl
Anti-pan ASIC (extracellular) Antibody
ASC-031 1 x 50 µl
Note Guinea pig polyclonal antibodies (#AGP-053 & #AGP-052) are included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
    • Acid-sensing ion channels (ASICs) are Na+ channels activated by external protons. ASIC4 is a member of the ASIC family that includes another three members: ASIC1ASIC2 and ASIC3. The ASIC family is in fact part of a large channel superfamily known as degenerin/epithelial Na+ channels (DEG/ENaC) and share the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N and C termini.

      The functional ASIC channel is composed of 4 subunits, which can form either a homo or heterotetramer. The subunit composition of the tetrameric channel will determine its biophysical properties such as pH sensitivity, inactivation kinetics and channel pharmacology. In fact, the ASIC4 protein does not appear to function as a proton-gated channel when expressed alone in heterologous systems and therefore a modulatory role for this subunit has been proposed.

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