ASIC1 Channel Premium Research Pack

All You Need for ASIC1 Channel Research
  • Lyophilized Powder
  • Antigen Incl.
  • Bioassay Tested
  • Shipped at Room Temp.
  • 100% Net Peptide
Cat #: ESP-200
Sizes: 9 Vials
Last update: 04/09/2018

Alomone Labs is pleased to offer the ASIC1 Channel Premium Research Pack (#ESP-200). The Research Pack contains all you need for ASIC1 channel research: Antibodies recognizing different domains of the channel and specific ASIC1 blockers and an activator, all in one economical package!

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-ASIC1 Antibody
ASC-014 1 x 0.2 ml
Guinea pig Anti-ASIC1 Antibody
AGP-053 1 x 0.2 ml
Anti-pan ASIC (extracellular) Antibody
ASC-031 1 x 0.2 ml
Mambalgin-3
M-300 1 x 35 µg
alpha/beta MitTx
M-100 1 x 5 µg
Psalmotoxin-1
STP-200 1 x 0.1 mg
Note A guinea pig polyclonal antibody (#AGP-053) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

ASIC1 is a member of a family of Na+ channels that are activated by external protons. The family includes another three members ASIC2ASIC3 and ASIC4.

The ASICs are in fact part of a larger superfamily termed epithelial Na+ channels (EnaC) and share with it the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N- and C- termini.  

There are two recognized splice variants of the ASIC1 gene that differ on their N-termini, ASIC1a and ASIC1b that have different tissue distributions and functions.  

The ASIC1 responds to a decrease in extracellular pH with an inward cation current that is quickly inactivated despite the continuous presence of protons in the medium.

Lately, ASIC1 has been implicated in processes such as learning and memory in the central nervous system.

References
  1. Kellenberger, Set al. (2002) Physiol. Rev. 82, 735.
  2. Wemmie, J. Aet al. (2002) Neuron 34, 463.
  3. Wemmie, J. Aet al. (2003) J. Neurosci. 23, 5496.
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