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A Potent Antagonist of 5-HT3 Channels and a Selective Noradrenaline Reuptake Inhibitor

Cat #: M-190
Alternative Name DDP-225
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 328.4
    Purity: >98%
    Effective concentration 10 nM - 1 µM.
    Chemical name 4-(2-fluorophenyl)-6-methyl-2-piperazin-1-ylthieno[2,3-d]pyrimidine.
    Molecular formula C17H17FN4S.
    CAS No.: 135991-48-9
    PubChem CID 131927
    Activity MCI-225 shows high affinity for the 5-HT3 receptor, Ki less than 100 nmol/L1.
    1. Eguchi, J. et al. (2001) Pharmacol. Biochem. Behav68, 677.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 30 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs MCI-225 blocks 5-HT3A receptors expressed in HEK 293T cells.
      Alomone Labs MCI-225 blocks 5-HT3A receptors expressed in HEK 293T cells.
      5-HT3A receptor currents were elicited by 10 µM 5-HT, delivered every 3 minutes. MCI-225 (#M-190) was applied 30 seconds before stimulation at 10 and 100 nM, as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
    References - Scientific background
    1. Eguchi, J. et al. (1994) Pharmacol. Biochem. Behav. 48, 345.
    2. Wu, Y.L. et al. (2000Jpn. J. Pharmacol. 83, 31.
    Scientific background

    MCI-225 is a psychoactive compound, a thienopyrimidine analogue that acts as a selective noradrenaline (NA) reuptake inhibitor with 5-HT3 channel blocking action. The compound demonstrates antidepressant-like activity with primary activity in the central nervous system.

    Several studies have shown that MCI-225 exhibits improvement in amnesia in scopolamine treated rats and in basal forebrain lesion rats. Acute administration of MCI-225 inhibits the rise of threshold induced by footshock stress1.

    It has been suggested that MCI-225 may affect attention, learning and memory2.

    Target 5-HT3A receptor, NET transporter
    Last update: 06/11/2022

    MCI-225 (#M-190) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Shipping and Ordering information