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MCI-225

DDP-225

A Potent Antagonist of 5-HT3 Channels and a Selective Noradrenaline Reuptake Inhibitor

Cat #: M-190
Alternative Name DDP-225
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 328.4
    Purity: >98%
    Effective concentration 10 nM - 1 µM.
    Structure
    Chemical name 4-(2-fluorophenyl)-6-methyl-2-piperazin-1-ylthieno[2,3-d]pyrimidine.
    Molecular formula C17H17FN4S.
    CAS No.: 135991-48-9
    PubChem CID 131927
    Activity MCI-225 shows high affinity for the 5-HT3 receptor, Ki less than 100 nmol/L1.
    References-Activity
    1. Eguchi, J. et al. (2001) Pharmacol. Biochem. Behav. 68, 677.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 30 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs MCI-225 blocks 5-HT3A receptors expressed in HEK 293T cells.
      Alomone Labs MCI-225 blocks 5-HT3A receptors expressed in HEK 293T cells.
      5-HT3A receptor currents were elicited by 10 µM 5-HT, delivered every 3 minutes. MCI-225 (#M-190) was applied 30 seconds before stimulation at 10 and 100 nM, as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
    References - Scientific background
    1. Eguchi, J. et al. (1994) Pharmacol. Biochem. Behav. 48, 345.
    2. Wu, Y.L. et al. (2000) Jpn. J. Pharmacol. 83, 31.
    Scientific background

    MCI-225 is a psychoactive compound, a thienopyrimidine analogue that acts as a selective noradrenaline (NA) reuptake inhibitor with 5-HT3 channel blocking action. The compound demonstrates antidepressant-like activity with primary activity in the central nervous system.

    Several studies have shown that MCI-225 exhibits improvement in amnesia in scopolamine treated rats and in basal forebrain lesion rats. Acute administration of MCI-225 inhibits the rise of threshold induced by footshock stress1.

    It has been suggested that MCI-225 may affect attention, learning and memory2.

    Target 5-HT3A receptor, NET transporter
    Lyophilized Powder
    Last update: 06/11/2022

    MCI-225 (#M-190) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use
    Shipping and Ordering information

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