Mechanosensitive K2P Channel Antibody Explorer Kit

A Screening Package of Mechanosensitive K2P Channel Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
  • QC Tested
  • Shipped at Room Temp.
Cat #: AK-306
Sizes: 10 Vials
Last update: 22/07/2018

Alomone Labs is pleased to offer the Mechanosensitive K2P Channel Antibody Explorer Kit (#AK-306). This Explorer Kit includes Mechanosensitive K2P Channel antibodies with their respective peptide control antigen. An ideal tool for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-K2P10.1 (TREK-2) Antibody
APC-055 1 x 50 µl
Anti-K2P18.1 (TRESK) (extracellular) Antibody
APC-122 1 x 50 µl
Anti-K2P4.1 (TRAAK) Antibody
APC-108 1 x 50 µl
Anti-K2P2.1 (TREK-1) Antibody
APC-047 1 x 50 µl
Guinea pig Anti-K2P2.1 (TREK-1) Antibody
AGP-049 1 x 50 µl
Note A Guinea pig polyclonal antibody (#AGP-049) is included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

Mechanosensitive ion channels (MS channels) represent a diverse population of ion channels. Other membrane-associated proteins with different biophysical properties apart from ion channels, specialized cytoskeletal proteins, cell junction molecules and G-protein-coupled receptors and kinases, among many others are also considered mechanosensitive1. MS channels integrate a variety of mechanical stimuli such as shear stress, tension, torsion, and compression and translate them into short-term effects (i.e., changes in ion concentrations and voltage) and long-term effects via changes in gene expression2

MS channels are detected throughout evolution, from bacteria to higher order organisms including mammals3.

Two primary models have been proposed for mechanogating: the lipid bilayer stretch model evidenced by microbial MS channels and the more sophisticated tether model of eukaryotes by which tethers pull open the transduction channel4.

Recent studies have demonstrated that defects in mechanosensing potentially lead to diverse diseases and disorder, such as hearing loss, cardiomyopathies, muscular dystrophies, chronic pain, and cancer5.

References
  1. Anishkin, A. et al. (2013) Proc. Natl. Acad. Sci. U.S.A. 110, 4886.
  2. Delmas, P. et al. (2011) Nat. Rev. Neurosci. 12, 139.
  3. Pivetti, C.D. et al. (2003) Microbiol. Mol. Biol. Rev67, 66.
  4. Arnadottir, J. et al. (2010) Annu. Rev. Biophys39, 111.
  5. Delmas, P. et al. (2013) Cell. 155, 278.
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