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P2X Receptor Antibody Explorer Kit

A Screening Package of P2X Receptor Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-201
Sizes: 28 Vials
Last update: 23/04/2019

Alomone Labs is pleased to offer the P2X Antibody Explorer Kit (#AK-201). This Explorer Kit includes antibodies targeted against P2X receptors along with their respective peptide control antigen. An ideal tool for screening purposes.

For research purposes only, not for human use
Compounds
Scientific Background
Scientific Background

The P2X receptors belong to the ligand-gated ion channel family and are activated by extracellular ATP.

The structure and function of the P2X receptors, investigated mainly using in vitro models, indicate their involvement in synaptic communication, cell death, and differentiation.

Seven mammalian P2X receptor subtypes (P2X1–P2X7) have been identified and cloned1-3. All P2X receptor subtypes share the same structure of intracellular N- and C-termini two membrane-spanning domains and a large extracellular loop.

All P2X receptor subtypes can assemble to form homomeric or heteromeric functional channels with the exception of P2X6, which only seems to function as part of a heteromeric complex4-9.

The various P2X receptor subtypes show distinct expression patterns. P2X1-6 have been found in the central and peripheral nervous system, while the P2X7 receptor is predominantly found in cells of the immune system4. The P2X1 receptor is present in smooth muscle, cerebellum, dorsal horn spinal neurons, and platelets where it is suggested to play a regulatory role during in vivo homeostasis and thrombosis3,4,10,11.
References
  1. Oury, C. et al. (2003) Blood 101, 3969.
  2. Florenzano, F. et al. (2002) Neuroscience 115, 425.
  3. Burnstock, G. (2001) Trends Pharmacol. Sci. 22, 182.
  4. Dunn, P.M. et al. (2001) Prog. Neurobiol. 65, 107.
  5. Khakh, B.S. et al. (2001) Pharmacol. Rev. 53, 107.
  6. Kim, M. et al. (2001) EMBO J. 20, 6347.
  7. Prasad, M. et al. (2001) J. Physiol. 537, 667.
  8. Robertson, S.J. et al. (2001) Curr. Opin. Neurobiol. 11, 378.
  9. Ashcroft, F.M. et al. (2000) Ion Channels and Disease Ed 1, p. 405, Academic Press, San Diego.
  10. Ding, Y. et al. (2000) J. Auton. Nerv. Syst. 81, 289.
  11. Lê, K.T. et al. (1998) J. Neurosci. 18, 7152.
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