Overview
P2X7 Receptor Premium Research Pack (#ESP-710) contains all you need for P2X7 receptor research: P2X7 receptor -specific antibodies and pharmacological tools, all in one budget friendly package!
Compounds
| Product Name | Cat # | Size |
|---|---|---|
| Antibodies | ||
Anti-P2X7 Receptor Antibody |
APR-004 | 1 x 0.2 ml |
P2X7 Receptor Blocking Peptide |
BLP-PR004 | 1 x 40 µg |
Anti-P2X7 Receptor (extracellular) Antibody |
APR-008 | 1 x 0.2 ml |
P2X7 Receptor (extracellular) Blocking Peptide |
BLP-PR008 | 1 x 40 µg |
| Activators/Agonists | ||
BzATP triethylammonium salt |
A-385 | 1 x 10 mg |
| Blockers/Antagonists | ||
JNJ-47965567 |
J-115 | 1 x 25 mg |
KN-62 |
K-120 | 1 x 10 mg |
ZINC9315614 |
Z-145 | 1 x 25 mg |
| Modulators | ||
Garcinolic acid |
G-155 | 1 x 1 mg |
GW 791343 hydrochloride |
G-115 | 1 x 25 mg |
Scientific Background
The P2X7 purinergic receptor is a member of the ionotropic P2X receptor family that is activated by ATP. To date, this family consists of seven receptor subtypes, named P2X1-P2X7, all of which have been cloned.
The various P2X receptors show distinct expression patterns. P2X1-6 receptors have been found in the central and peripheral nervous system, while the P2X7 receptor is found in cells of the immune system, particularly in antigen-presenting cells and microglia.
The P2X7 receptor mediates the release of proinflamatory cytokines and stimulation of transcription factors and may also play an important role in apoptosis1-3.
- Ding, Y. et al. (2000) J. Auton. Nerv. Syst. 81, 289.
- Kim, M. et al. (2001) EMBO J. 20, 6347.
- Chizh, B.A. and Illes, P. (2001) Pharmacol. Rev. 53, 553.
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Resources
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