This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
Werkman, T.R. et al. (1993) Mol. Pharmacol. 44, 430.
Alomone Labs Tityustoxin-Kα inhibits KV1.2 currents in Xenopus oocytes.A. Time course of Tityustoxin-Kα (#STT-360) action on KV1.2 currents. Plateau current amplitudes were plotted as a function of time. Membrane potential was held at –100 mV and oocytes were stimulated by a 100 ms voltage step to +20 mV. 1 nM Tityustoxin-Kα was perfused as indicated by the bar (green). B. Superimposed examples of KV1.2 channel current in the absence (control) and presence of 1 nM Tityustoxin-Kα (taken from the experiment in A).
Tityustoxin-Kα was originally isolated from the scorpion Tityus serrulatus, and was shown to block cloned KV1.2 with high potency.1 It inhibits stably expressed KV1.2 channels in fibroblast cell line as assessed by patch clamp with Kd of 0.21 nM1. Tityustoxin-Kα also reduced the binding of 125I-α-Dendrotoxin to synaptosomal membranes2.
Tityustoxin-Kα (#STT-360) is a highly pure, synthetic, and biologically active peptide toxin.