Every lot is tried & tested in a relevant biological assay.
Our Bioassay
- Peigneur, S. et al. (2016) Biochemistry. 55, 2927.
- Alomone Labs Spinoxin blocks KV1.2 channels expressed in Xenopus oocytes.A. Representative time course of Spinoxin (#STS-500) inhibition of KV1.2 current. Membrane potential was held at -100 mV, current was elicited by a 100 ms voltage ramp to +50 mV every 10 sec, and reversibly inhibited by application of 0.1 nM and 1 nM Spinoxin (indicated by bars). B. Superimposed traces of KV1.2 current after the application of control, 0.1 nM and 1 nM Spinoxin (as indicated). Taken from the recording in A.
- Peigneur, S. et al. (2016) Biochemistry. 55, 2927.
- Yamaguchi, Y. et al. (2016) Toxicon 122, 31.
Spinoxin (SPX, α-KTx6.13) is a 34-residue peptide toxin originally isolated from the scorpion Heterometrus spinifer venom. Spinoxin is a potent KV1.3 channel blocker displaying IC50 values of 63 nM. It also has high affinity towards KV1.2 channels1,2.
K+ ion channels play an important role in the modulation of Ca2+ signaling by controlling the membrane potential. These channels are considered to be very important targets in the diagnostics and therapy in several autoimmune disorders and cancers1.
Spinoxin (#STS-500) is a highly pure, synthetic, and biologically active peptide toxin.
Applications
Specifications
Scientific Background
Citations
Related Products
Antibodies
- Anti-KV1.2 (KCNA2) (extracellular) Antibody (#APC-162)
- Anti-KV1.2 (KCNA2) Antibody (#APC-010)
- Anti-KV1.3 (KCNA3) (extracellular) Antibody (#APC-101)
- Anti-KV1.3 (KCNA3) (extracellular)-Biotin Antibody (#APC-101-B)
- Anti-KV1.3 (KCNA3) (extracellular)-FITC Antibody (#APC-101-F)
- Anti-KV1.3 (KCNA3) (extracellular)-PE Antibody (#APC-101-PE)
- Anti-KV1.3 (KCNA3) Antibody (#APC-002)
- Guinea pig Anti-KV1.3 (KCNA3) (extracellular) Antibody (#AGP-005)
Pharmacological tools
Resources
Need Help With This Product?
Our reagent specialists are here to help you find the best product for your application. Please call or email us and we will be happy to help you find the right product for the job.
Call us at
+972 2587 2202 or Email Us