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β-Dendrotoxin

A Potent Blocker of KV1.1 and KV1.2 Channels

Cat #: D-360
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Natural peptide isolated from Dendroaspis angusticeps (Eastern green mamba).
    MW: ~7000 Da
    Purity: >98% (HPLC)
    Effective concentration 10-500 nM.
    Activity β-Dendrotoxin inhibits 4-AP sensitive, inactivating voltage-gated K+ channels (KV1.1, KV1.2).
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs β-Dendrotoxin inhibits cloned KV1.1 and KV1.2 channel currents heterologously expressed in Xenopus oocytes.
      Alomone Labs β-Dendrotoxin inhibits cloned KV1.1 and KV1.2 channel currents heterologously expressed in Xenopus oocytes.
      KV1.1 (left, in 2 mM K+) and KV1.2 (right, in 5 mM K+) channel currents, elicited by 200 ms depolarization from holding potential of -100 mV to +20 mV, before and during application of 100 nM β-Dendrotoxin (#B-360). 62% (n = 4) of the KV1.1 and 74% (n = 4) of the KV1.2 channels were inhibited by 100 nM β-Dendrotoxin, respectively.
    References - Scientific background
    1. Benishin, C.G. et al. (1988) Mol. Pharmacol34, 152.
    2. Harvey, A.L. and Anderson, A.J. (1985) Pharmacol. Ther31, 33.
    Scientific background β-Dendrotoxin is found in the Dendroaspis angusticeps snake venom1,2. It blocks KV1.1 and KV1.2 channels expressed in Xenopus oocytes.
    Target KV1.1, KV1.2 K+ channels
    Peptide Content: 100%
    Last update: 29/08/2021

    β-Dendrotoxin (#D-360) is a highly pure, natural, and biologically active peptide toxin.

    For research purposes only, not for human use
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