Every lot is tried & tested in a relevant biological assay.
Our Bioassay
- Watanabe, T. et al. (2005) Hypertension 45, 163.
- Brasch, H. et al. (1993) Hypertension 22, 699.
- Shi, H.X. et al. (2014) Evid. Based Complement. Alternat. Med. 2014, 682041.
Angiotensin II (Ang II) is a natural ligand and a potent angiotensin type 1 and 2 (AT2R and AT1R) receptor agonist. It is important for maintaining normal regulation of cardiovascular function. Ang II is a primary effector peptide of the renin-angiotensin system (RAS) in a variety of tissues and is a major target for blood pressure lowering drugs. Ang II is also responsible for the release of catecholamines from the adrenal medulla and from dopaminergic neurons in the central nervous system1.
Angiotensin I is metabolized to the vasoconstricting octapeptide angiotensin II by a circulating converting enzyme (ACE) by removal of two C-terminal residues.
Several studies have suggested that increased levels of Ang II in the blood flow may cause endothelial cell dysfunction during the pathogenesis of conditions such as atherosclerosis and hypertension2.
Angiotensin II acetate (#SPA-165) is a highly pure, synthetic, and biologically active peptide.
Applications
Citations
Specifications
Scientific Background
Related Products
Antibodies
- Anti-Angiotensin II Receptor Type-1 (extracellular) Antibody (#AAR-011)
- Anti-Angiotensin II Receptor Type-1 (extracellular)-FITC Antibody (#AAR-011-F)
- Anti-Angiotensin II Receptor Type-2 (extracellular) Antibody (#AAR-012)
- Anti-Angiotensin II Receptor Type-2 (extracellular)-ATTO Fluor-488 Antibody (#AAR-012-AG)
Pharmacological tools
Explorer kits & Research packs
Need Help With This Product?
Our reagent specialists are here to help you find the best product for your application. Please call or email us and we will be happy to help you find the right product for the job.
Call us at
+972 2587 2202 or Email Us