Angiotensin II acetate

A Potent Agonist of Angiotensin II Receptors 
    Cat #: SPA-165
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1046 Da.
    Purity: ≥98% (HPLC)
    Effective concentration 1-300 nM.
    Sequence DRVYIHPF.
    Structure
    • Angiotensin II acetate
    Molecular formula C50H71N13O12.
    CAS No.: 4474-91-3.
    Activity An Angiotensin II Type 1 and Type 2 Receptor Agonist1.
    References-Activity
    1. Watanabe, T. et al. (2005) Hypertension 45, 163.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in water. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Angiotensin II acetate
      Alomone Labs Angiotensin II Acetate activates AT1R expressed in CHO-K1-mt Aequorin-Gα16 cells.
      Ca2+ response was detected by measuring aequorin-derived fluorescence following application of Angiotensin II Acetate (#SPA-165).
    References - Scientific background
    1. Brasch, H. et al. (1993) Hypertension 22, 699.
    2. Shi, H.X. et al. (2014) Evid. Based Complement. Alternat. Med. 2014, 682041.
    Scientific background

    Angiotensin II (Ang II) is a natural ligand and a potent angiotensin type 1 and 2 (AT2R and AT1R) receptor agonist. It is important for maintaining normal regulation of cardiovascular function. Ang II is a primary effector peptide of the renin-angiotensin system (RAS) in a variety of tissues and is a major target for blood pressure lowering drugs. Ang II is also responsible for the release of catecholamines from the adrenal medulla and from dopaminergic neurons in the central nervous system1.

    Angiotensin I is metabolized to the vasoconstricting octapeptide angiotensin II by a circulating converting enzyme (ACE) by removal of two C-terminal residues.

    Several studies have suggested that increased levels of Ang II in the blood flow may cause endothelial cell dysfunction during the pathogenesis of conditions such as atherosclerosis and hypertension2.

    Target Angiotensin II receptors
    Net Peptide Content: 100%
    Last update: 24/01/2020

    Angiotensin II acetate (#SPA-165) is a highly pure, synthetic, and biologically active peptide.

    For research purposes only, not for human use
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