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This product is freeze dried. All water molecules have been removed.
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Peptide CDFGDGMKEVPSVNLR, corresponding to amino acid residues 430-445 of rat KV9.2 (Accession Q9ER26). Intracellular, C-terminus.
Western blot analysis of mouse brain lysate:1. Anti-KCNS2 (KV9.2) Antibody (#APC-132), (1:200).
2. Anti-KCNS2 (KV9.2) Antibody, preincubated with the control peptide antigen.Western blot analysis of rat brain lysate:1. Anti-KCNS2 (KV9.2) Antibody (#APC-132), (1:200).
2. Anti-KCNS2 (KV9.2) Antibody, preincubated with the control peptide antigen.
KV9.2 is a member of the electrically silent voltage-gated K+ (KV). Ten KV silent subunits have been identified: KV5.1, KV6.1–KV6.4, KV8.1, KV8.2, and KV9.1–KV9.3. KV9.2 modulates the activity of KV2.1 and KV2.2 channels1,2. KV9.2 structure includes six transmembrane segments: S1–S6, positive residues on S4, the K+ signature sequence GYG on the pore loop between S5 and S6, and cytoplasmic N and C termini2.
High KV9.2 expression level can be found in the olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei, and cerebellum1.
Species reactivity key:
Anti-KCNS2 (KV9.2) Antibody (#APC-132) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize KV9.2 channel from human, rat, and mouse samples.