This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
Padilla, K. et al. (2009) Neurosci. Lett. 465, 138.
Alomone Labs ICA-27243 modulate KCNQ2/KCNQ3 voltage-gated K+ currents expressed in Xenopus oocytes.A. Time course of KCNQ2/KCNQ3 current enhancement by 2 and 10 µM ICA-27243 (#I-130) as measured at -25 mV. Currents were elicited by application of voltage ramp from a holding potential of -100 mV to 0 mV (800 msec).
B. Superimposed example traces of current responses before and during perfusion of 10 µM ICA-27243 as indicated.
- Wickenden, A.D. et al. (2008) Mol. Pharmacol. 73, 977.
KCNQ2 (KV7.2) and KCNQ3 (KV7.3) are voltage-gated K+ channel subunits that underlie the neuronal M current. ICA-27243 is a novel, potent and selective activator of M-current and KCNQ2/Q3 channels. ICA-27243 is structurally distinct from other known KCNQ/M-current activators. It enhances KCNQ channel activation by shifting channel opening to more hyperpolarized potentials. ICA-27243 activates KCNQ currents in Chinese hamster ovary cells expressing recombinant KCNQ2/Q3 heteromultimeric channels with an EC50 of 0.4 μM. ICA-27243 exhibits selectivity for KCNQ2/Q3 over KCNQ4 (20-fold) and KCNQ3/Q5 (>100-fold) and has no effect on GABA-activated chloride channels, neuronal Na+ channels, or voltage-gated Ca2+ channels. In addition, it produces minimal displacement of radioligand binding to a range of central nervous system receptors and transporters. ICA-27243 also suppresses seizure-like activity in an ex vivo hippocampal slice model, and protects against maximal electroshock-induced seizures in mice1.
ICA-27243 (#I-130) is a highly pure, synthetic, and biologically active compound.
- Retigabine (#R-100)
- Retigabine dihydrochloride (#R-101)
- SsTx Toxin (#STS-700)
- Flupirtine Maleate (#F-150)
- Anti-KCNQ2 Antibody (#APC-050)
- Anti-KCNQ3 Antibody (#APC-051)
- Anti-KCNQ1 Antibody (#APC-022)
- Anti-KCNQ5 Antibody (#APC-155)
- Anti-KCNE2 (MiRP1) Antibody (#APC-054)
- Anti-KCNE3 (MiRP2) Antibody (#APC-118)
- KCNQ (KV7) Channel Antibody Explorer Kit (#AK-221)