This product has recently been released.
This product is freeze dried. All water molecules have been removed.
The activity of this product has been verified and approved by our professional team.
This lyophilized product is shipped at room temperature. Please see its certificate of analysis for further storage instructions.
This vial contains 100% net peptide content.
Results were kindly provided by Prof. Anastasios Tzingounis, Dept. of Physiology & Neurobiology, University of Connecticut, USA.
SsTx Toxin is a peptide toxin originally isolated from the Chinese red-headed centipede venom. SsTx structure consists of amino acids in position 12 and 13 which form a positively charged surface and two disulphide bridges. It is the first peptide toxin found to potently and selectively block KCNQ (KV7) channels, members of voltage-gated potassium (KV) channel family1 with IC50 values of 2.5, 2.8, 2.7, and 2.7 μM for KCNQ4, KCNQ1, KCNQ2, and KCNQ5 respectively1.
SsTx blocks progressively less when the membrane potential becomes more depolarized, and high K+ concentrations increase the IC50 values, suggesting that the toxin binds to the outer pore domain of KCNQ channels1.
KCNQ is a family of multifunctional K+ channels that are involved in a variety of physiological functions, including cardiac action potential repolarization, coronary circulation and reactive hyperemia, and cerebral neuron excitation. These channels are considered to be potential therapeutic targets for a variety of neuronal disorders1,2.
SsTx Toxin (#STS-700) is a highly pure, synthetic, and biologically active peptide toxin.