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4-5. Anti-KCNQ5 Antibody, preincubated with the control peptide antigen.
KCNQ genes encode members of the KV7 K+ channels. Structurally, the KCNQ family belongs to the six transmembrane domain category of K+ channels. Five members belong to this family (KCNQ1-KCNQ5) of which KCNQ2 to KCNQ5 are expressed in the nervous system1-3. KCNQ5 is also expressed in visceral smooth muscle4 and skeletal muscle5.
These channels form subunits of the low threshold voltage gated K+ channel. KCNQ2 and KCNQ3 mostly form heteromers to form the M current. KCNQ5 is known to contribute to this current1.
Species reactivity key:
Expression of KV7.5 (KCNQ5) in swine coronary artery.Immunohistochemical staining of swine coronary artery sections using Anti-KCNQ5 Antibody (#APC-155). KV7.5 staining (brown) is mostly detected in the intimal layer (I). Much lower staining is observed in medial layer (M).Adapted from Chen, X. et al. (2016) PLoS ONE 11, e0148569. with permission of PLoS.
Anti-KCNQ5 Antibody (#APC-155) is a highly specific antibody directed against an epitope of the mouse KV7.5 channel. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize KCNQ5 from rat, mouse, and human samples.
Adapted from Morales-Cano, D. et al. (2015) with permission of the European Society of Cardiology.
- Rat smooth muscle cells (1:500).
Morales-Cano, D. et al. (2015) Cardiovasc. Res. 106, 98.
Blockers/Antagonists: peptides/peptide toxinsBlockers/Antagonists: small moleculesActivators/Agonists: small molecules