Lyophilized Powder This product is freeze dried. All water molecules have been removed.
Antigen Incl. This antibody is shipped with its antigen FREE of charge!
Shipped at Room Temp. This lyophilized product is shipped at room temperature. Please see its certificate of analysis for further storage instructions.
Alomone Labs is pleased to offer the KCNQ (KV7) Channel Antibody Explorer Kit (#AK-221). This Explorer Kit includes antibodies targeted against KCNQ channels and subunits along with their respective peptide control antigen. An ideal tool for screening purposes.
| Product Name | Cat # | Size |
|---|---|---|
Anti-KCNQ1 Antibody | APC-022 | 1 x 50 µl |
Anti-KCNQ1 (extracellular) Antibody | APC-168 | 1 x 50 µl |
Anti-KCNQ2 Antibody | APC-050 | 1 x 50 µl |
Anti-KCNQ3 Antibody | APC-051 | 1 x 50 µl |
Anti-KCNQ4 Antibody | APC-164 | 1 x 50 µl |
Anti-KCNQ5 Antibody | APC-155 | 1 x 50 µl |
Anti-KCNE1 (IsK) Antibody | APC-163 | 1 x 50 µl |
Anti-KCNE2 (MiRP1) Antibody | APC-054 | 1 x 50 µl |
Anti-KCNE3 (MiRP2) Antibody | APC-118 | 1 x 50 µl |
Anti-KCNE4 (MiRP3) Antibody | APC-129 | 1 x 50 µl |
The KCNQ family of voltage-gated K+ channels includes 5 known members: KCNQ1 to KCNQ5. Structurally, the KCNQ family belongs to the six transmembrane domain category of K+ channels. KCNQ family members can form either homomultimeric or heteromultimeric channels with different functional consequences. For example, KCNQ2 and KCNQ3 heteromultimers give rise to a much larger channel current than when either protein is expressed alone, probably due to enhanced plasma membrane expression of the combined channel. Indeed, KCNQ2/KCNQ3 heteromultimers are believed to be the molecular correlates of the so-called M current. This current is a K+ neuronal current that is strongly inhibited by the activation of the M1 subtype of the muscarinic acetylcholine receptor. KCNQ5 is also expressed in visceral smooth muscle4 and skeletal muscle.
