Overview
Cat #: AK-209
Size: 19 Vials
Form: Lyophilized
Alomone Labs is pleased to offer the Store-Operated Ca2+ Channel Antibody Explorer Kit (#AK-209). This Explorer Kit includes antibodies targeted against CRAC channels along with their respective peptide control antigen (excludes mouse monoclonal antibodies). An ideal tool for screening purposes.
For research purposes only, not for human use
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-Orai1 (extracellular) Antibody |
ACC-062 | 1 x 50 µl |
Orai1 (extracellular) Blocking Peptide |
BLP-CC062 | 1 x 40 µg |
Anti-Human Orai1 (extracellular) Antibody |
ACC-060 | 1 x 50 µl |
Human Orai1 (extracellular) Blocking Peptide |
BLP-CC060 | 1 x 40 µg |
Mouse Anti-Human Orai1 (extracellular) Antibody |
ALM-025 | 1 x 25 µg |
Anti-Orai2 Antibody |
ACC-061 | 1 x 50 µl |
Orai2 Blocking Peptide |
BLP-CC061 | 1 x 40 µg |
Anti-Orai3 Antibody |
ACC-065 | 1 x 50 µl |
Orai3 Blocking Peptide |
BLP-CC065 | 1 x 40 µg |
Anti-TMEM66 Antibody |
ACC-067 | 1 x 50 µl |
TMEM66 Blocking Peptide |
BLP-CC067 | 1 x 40 µg |
Anti-STIM1 (extracellular) Antibody |
ACC-063 | 1 x 50 µl |
STIM1 (extracellular) Blocking Peptide |
BLP-CC063 | 1 x 40 µg |
Anti-STIM2 Antibody |
ACC-064 | 1 x 50 µl |
STIM2 Blocking Peptide |
BLP-CC064 | 1 x 40 µg |
Anti-TRPC1 Antibody |
ACC-010 | 1 x 50 µl |
TRPC1 Blocking Peptide |
BLP-CC010 | 1 x 40 µg |
Anti-TRPC1 (extracellular) Antibody |
ACC-118 | 1 x 50 µl |
TRPC1 (extracellular) Blocking Peptide |
BLP-CC118 | 1 x 40 µg |
Scientific Background
Scientific Background Changes in the cytoplasm free Ca2+ concentration [Ca2+]in regulate a large number of relevant physiological processes and have a major impact on cell development and function. The identification of STIM, the endoplasmic reticulum (ER) Ca2+ sensor, and Orai, a key subunit of the Ca2+ release-activated Ca2+ (CRAC) channel pore, have provided the tools to illuminate the mechanisms of CRAC channel regulation that play an important role in modulation of the free Ca2+ concentration in non-excitable cells. Store-operated Ca2+ entry (SOCE) is a common and ubiquitous mechanism for regulating Ca2+ influx into cells and is widely expressed in most tissues.
