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Eliprodil

SL 82-0715

An Antagonist of NMDA Receptors and N- and P-Type CaV Channels

Cat #: E-155
Alternative Name SL 82-0715
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 347.9
    Purity: >99%
    Effective concentration 0.1-10 µM.
    Structure
    Chemical name 1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanol.
    Molecular formula C20H23ClFNO.
    CAS No.: 119431-25-3
    PubChem CID 60703
    Activity Eliprodil is a non-competitive NR2B-selective NMDA glutamate receptor antagonist 1, N and P-type voltage-dependent Ca2+ channels blocker 2.
    References-Activity
    1. Avenet, P. et al. (1997) Neurosci. Lett. 223, 133.
    2. Bath, C.P. et al. (1996). Eur. J. Pharmacol. 299, 103.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility >25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Eliprodil inhibits specific binding of Ifenprodil to rat brain cortex NMDA receptors at polyamine sites.
      Alomone Labs Eliprodil inhibits specific binding of Ifenprodil to rat brain cortex NMDA receptors at polyamine sites.
      Percent inhibition of specific binding of 2 nM [3H] Ifenprodil to membranes from rat brain cerebral cortex, plotted against concentrations of Eliprodil (#E-155). Full inhibition is achieved at 3 µM.
    References - Scientific background
    1. Bath, C.P. et al. (1996). Eur. J. Pharmacol. 299, 103.
    2. Black, S.A. et al. (2014) Front. Cell. Dev. Biol. 2, 45.
    3. Layer, R.T. et al. (1995) Pharmacol. Biochem. Behav. 52, 621.
    Scientific background

    Eliprodil, also known as SL 82-0715, is a non-competitive NMDA (N-methyl-D-aspartate) receptor antagonist with neuroprotective properties. Eliprodil blocks the receptor through interaction with a modulatory polyamine site. The drug has also been shown to inhibit neuronal N- and P-type Ca2+ channel currents1.

    NMDARs play an important role in a variety of cellular processes and brain functions including synaptic plasticity, addiction and stroke. They also mediate physiological functions such as learning and memory formation. They play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer’s disease2.

    Studies show that eliprodil has the ability to protect against ischaemia-induced neurodegeneration when the drug is administered post-occlusion and demonstrates antidepressant-like actions in preclinical tests predictive of clinical efficacy1,3.

    Target NMDA receptors, N-, P-type CaV channels
    Lyophilized Powder
    Last update: 06/11/2022

    Eliprodil (#E-155) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use
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