TTX-Sensitive NaV Channel Blocker Explorer Kit

A Screening Package of TTX-Sensitive NaV Channel Blockers Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
  • Shipped at Room Temp.
Cat #: EK-105
Sizes: 35 Vials
Last update: 03/09/2018

Alomone Labs is pleased to offer the TTX-Sensitive NaV Channel Blocker Explorer Kit (#EK-105). This Explorer Kit includes both classical and novel NaV blockers, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Ambroxol hydrochloride
A-145 1 x 1 g
Bupivacaine hydrochloride
B-125 1 x 1 g
Carbamazepine
C-105 1 x 5 g
Ceratotoxin-2
STC-100 1 x 50 µg
µ-Conotoxin CnIIIC
STC-640 1 x 50 µg
µ-Conotoxin GIIIB
C-270 1 x 50 µg
µ-Conotoxin KIIIA
C-280 1 x 50 µg
µ-Conotoxin PIIIA
STC-400 1 x 50 µg
µ-Conotoxin SIIIA
STC-450 1 x 50 µg
GrTx1
STG-250 1 x 50 µg
GsAF-I
STG-300 1 x 50 µg
GsAF-II
STG-350 1 x 50 µg
GsMTx-4
STG-100 1 x 0.1 mg
GTx1-15
STT-300 1 x 50 µg
Huwentoxin-IV
STH-100 1 x 0.1 mg
mHuwentoxin-IV
STH-101 1 x 50 µg
Lidocaine
L-105 1 x 10 g
Lidocaine hydrochloride
L-145 1 x 25 g
Lorcainide HCl
L-135 1 x 5 mg
Mepivacaine hydrochloride
M-110 1 x 250 mg
Mexiletine hydrochloride
M-115 1 x 1 g
Oxcarbazepine
O-105 1 x 5 mg
Phrixotoxin-3
STP-720 1 x 50 µg
Pilsicainide hydrochloride
P-145 1 x 5 mg
ProTx-I
STP-400 1 x 50 µg
ProTx-II
STP-100 1 x 50 µg
Pterinotoxin-1
STT-100 1 x 0.1 mg
QX-222 chloride
Q-200 1 x 10 mg
QX-314 bromide
Q-100 1 x 100 mg
QX-314 chloride
Q-150 1 x 50 mg
Ralfinamide mesylate
R-105 1 x 5 mg
Ranolazine
R-110 1 x 10 mg
Tetrodotoxin citrate free
T-500 1 x 1 mg
Tetrodotoxin citrate
T-550 1 x 1 mg
Tolperisone hydrochloride
T-115 1 x 25 mg
References
Scientific Background

Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow thr flow of Na+ ions.

To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5  The NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7)  and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific.

References
  1. Lai, J. et al. (2003) Curr. Opin. Neurobiol 13, 291.
  2. Fang, X. et al. (2002) J. Neurosci22, 7425.
  3. Wu, L. et al. (2002) NeuroReport 13, 2547.
  4. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27.
  5. Fjell, J. et al. (2000) NeuroReport 11, 199.
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