This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
- Luna-Ramirez K. et al. (2014) Mol. Pharmacol. 86, 28.
- Alomone Labs Urotoxin blocks KV1.2 channels expressed in Xenopus oocytes.A. Representative time course of Urotoxin (#STU-200) inhibition of KV1.2 current. Membrane potential was held at -100 mV, current was elicited by a 100 ms voltage ramp to +40 mV every 10 sec, and significantly inhibited by 0.1 nM Urotoxin (green). B. Superimposed traces of KV1.2 current after application of control (black) and of 0.1 nM Urotoxin (green), taken from the recording in A.
Urotoxin is a peptide toxin originally isolated from Urodacus yaschenkoi Australian Scorpion venom. Urotoxin is an extremely potent blocker of human voltage-gated potassium channel KV1.2 channels with IC50 values of 160 pM. However, it also displays activity towards KV1.1, KV1.3 and KCa3.1 with IC50 values of 253 nM, 91 nM and 70 nM respectively1.
Potassium channels are membrane proteins found in excitable and nonexcitable cells. KV1.2 channel plays an important role in the maintenance of resting membrane potential and the regulation of the cellular excitability of neurons1,2.
Urotoxin (#STU-200) is a highly pure, synthetic, and biologically active peptide toxin.