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A Blocker of KCa1.1 (BK) Channels

Cat #: V-500
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Penicillium simplicissimum.
    Source Natural
    MW: 511.23
    Purity: >98%
    Effective concentration 10-100 nM.
    Chemical name 5H,12H-3,4-Dioxa-5a,11a,15atriazacyclooct(lm)indeno(5,6-b)fluorene-11,15(2H,13H)-dione,1,10,10a,14,14a,15b-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-,(5R,10S,10aR,14aS,15bS).
    Molecular formula C27H33N3O7.
    CAS No.: 12771-72-1
    Activity Verruculogen is a selective blocker of KCa1.1 (BK) channel. It belongs to a set of tremorgenic indole alkaloids1.
    1. Knaus, H.G. et al. (1994) Biochemistry 33, 5819.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO, methanol or acetone.
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
    Our bioassay
    • Verruculogen inhibits KCa1.1 channels in Xenopus oocytes.
      Verruculogen inhibits KCa1.1 channels in Xenopus oocytes.
      Time course of KCa1.1 channel current amplitude upon application of several mycotoxins, including Verruculogen (#V-500). Current amplitude was reduced by 100 nM Paxilline (#P-450), (a), Penitrem A (#P-650), (b) and Verruculogen (c). The horizontal bars represent the period of toxin perfusion.
    References - Scientific background
    1. Selala, M.I. et al. (1991) J. Nat. Prod54, 207.
    2. Knaus, H.G. et al. (1994) Biochemistry 33, 5819.
    3. Akoi, T. and Baraban, S. C. (2000) J. Neurophysiol. 83, 3453.
    Scientific background

    Verruculogen is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Penitrem A (#P-650) and Paxilline (#P-450).2

    Verruculogen enhanced the electrically induced twitch contractions in guinea pig ileum, without influencing the contractions provoked by exogenous acetylcholine.1 Verruculogen had similar effects to Iberiotoxin (#STI-400) in inhibiting the early Ca2+ dependent K+ current in CA1 pyramidal cells.3

    Target KCa1.1 Kchannels
    Last update: 02/01/2022

    Verruculogen (#V-500) is a highly pure, natural, and biologically active compound.

    For research purposes only, not for human use



    Product citations
    1. Ishii, H. et al. (2010) Eur. J. Neurosci. 32, 736.


    Scientific Background

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