This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
- Knaus, H.G. et al. (1994) Biochemistry 33, 5819.
- Verruculogen inhibits KCa1.1 channels in Xenopus oocytes.
Verruculogen is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Penitrem A (#P-650) and Paxilline (#P-450).2
Verruculogen enhanced the electrically induced twitch contractions in guinea pig ileum, without influencing the contractions provoked by exogenous acetylcholine.1 Verruculogen had similar effects to Iberiotoxin (#STI-400) in inhibiting the early Ca2+ dependent K+ current in CA1 pyramidal cells.3