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CaV1.2 (CACNA1C) Channel Basic Research Pack

All You Need for CaV1.2 (CACNA1C) Channel Research
  • Lyophilized Powder
  • Antigen Incl.
  • Bioassay Tested
Cat #: ESB-100
Sizes: 8 Vials
Last update: 01/04/2019

Alomone Labs is pleased to offer the CaV1.2 (CACNA1C) Channel Basic Research Pack (#ESB-100). The Research Pack contains all you need for CaV1.2 research: Antibodies recognizing different domains of the channel, membrane lysates expressing CaV1.2 channel- your ideal control for western blot analysis and specific L-type CaV channel activators and blockers, all in one economical package!

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Anti-CaV1.2 (CACNA1C) Antibody
 		ACC-003 1 x 0.2 ml
Anti-Human CaV1.2 (CACNA1C) Antibody
 		ACC-022 1 x 0.2 ml
CaV1.2 (CACNA1C) Channel Overexpressed Membrane Fractions
 		LX-104 2 x 0.1 ml
(±)-Bay K8644
 		B-350 1 x 25 mg
Isradipine
 		I-100 1 x 10 mg
Note

CaV1.2 (CACNA1C) Channel Overexpressed Membrane Fractions includes:
1 x 0.1 ml lyophilized CaV1.2 channel overexpressed membrane fractions
1 x 0.1 ml lyophilized non-injected Xenopus oocyte membrane fractions
Scientific Background
Scientific Background

All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal, cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptors.

While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous and CaV1.3 channels are found in the heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channel blockers, but so far no selective blocker for one of the CaV1 isoforms have been described. These include the Mamba toxins Calcicludine (#SPC-650), Calciseptine (#C-500) and FS-2 (#F-700).
References
  1. Catterall, W.A. et al. (2003) Pharmacol. Rev. 55, 579.
  2. IUPHAR
  3. Hu, X.Q. et al. (1998) J. Biol. Chem. 273, 5337.
  4. Kreuzberg, U. et al. (2000) Am J. Physiol. 278, H723.
  5. Allard, B. et al. (2000) J. Biol. Chem. 275, 25556.
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